Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone.
about
Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Preferred binding orientations of phenacetin in CYP1A1 and CYP1A2 are associated with isoform-selective metabolism.NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylationConformational plasticity and structure/function relationships in cytochromes P450.Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactionsFunctional analysis of phenylalanine residues in the active site of cytochrome P450 2C9.Heterologous expression of CYP102A5 variant from Bacillus cereus CYPPB-1: Validation of model for predicting drug metabolism of human P450 probe substrates.
P2860
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P2860
Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Substrate proton to heme dista ...... terotropic activator, dapsone.
@en
type
label
Substrate proton to heme dista ...... terotropic activator, dapsone.
@en
prefLabel
Substrate proton to heme dista ...... terotropic activator, dapsone.
@en
P2093
P2860
P1476
Substrate proton to heme dista ...... terotropic activator, dapsone.
@en
P2093
Jarrett Aguilar
Matthew A Hummel
Peter M Gannett
Timothy S Tracy
P2860
P304
P356
10.1016/J.ABB.2008.04.034
P407
P577
2008-05-01T00:00:00Z