about
Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics.Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid PharmacophoreThe TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compoundsNew 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligandsFrog skin opioid peptides: a case for environmental mimicry.Dmt and opioid peptides: a potent alliance.Delta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.Conversion of enkephalin and dermorphin into delta-selective opioid antagonists by single-residue substitution.Conformational analysis of potent and very selective delta opioid dipeptide antagonists.Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.Probing the shape of a hydrophobic pocket in the active site of delta-opioid antagonists.Opioid diketopiperazines: synthesis and activity of a prototypic class of opioid antagonists.Design and solution structure of a partially rigid opioid antagonist lacking the basic center--models of antagonism.Design of mu selective opioid dipeptide antagonists.Conformational sampling of bioactive conformers: a low-temperature NMR study of 15N-Leu-enkephalin.
P2860
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P2860
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Selective opioid dipeptides.
@en
Selective opioid dipeptides.
@nl
type
label
Selective opioid dipeptides.
@en
Selective opioid dipeptides.
@nl
prefLabel
Selective opioid dipeptides.
@en
Selective opioid dipeptides.
@nl
P2093
P356
P1476
Selective opioid dipeptides.
@en
P2093
Lazarus LH
Salvadori S
Tancredi T
Temussi PA
P304
P356
10.1006/BBRC.1994.1133
P407
P577
1994-02-01T00:00:00Z