Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
about
Mutant p53: One, No One, and One Hundred ThousandThe Contrived Mutant p53 Oncogene - Beyond Loss of FunctionsMutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic markerMutant TP53 posttranslational modifications: challenges and opportunities.AKT regulates NPM dependent ARF localization and p53mut stability in tumors.The p53R172H mutant does not enhance hepatocellular carcinoma development and progression.Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.Molecular characterization of hepatocarcinogenesis using mouse modelsNovel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary diseaseAmino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.TP53 mutation predicts the poor prognosis of non-Hodgkin lymphomas: Evidence from a meta-analysis.p28, a first in class peptide inhibitor of cop1 binding to p53.Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53.A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress.Mutant p53 in cancer: new functions and therapeutic opportunities.The paradigm of mutant p53-expressing cancer stem cells and drug resistance.TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response.Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis.Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner.Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others.Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework.Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target.
P2860
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P2860
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
@zh-hant
name
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
@en
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
@nl
type
label
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
@en
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
@nl
prefLabel
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
@en
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
@nl
P2093
P1433
P1476
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
@en
P2093
Beng Hooi Phang
Kanaga Sabapathy
Ming Kei Lee
Wei Min Tong
Wei Wei Teoh
Zhao Qi Wang
P304
P356
10.1016/J.CCR.2012.10.022
P577
2012-12-01T00:00:00Z