Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues.
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Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductaseStructure of the open conformation of a functional chimeric NADPH cytochrome P450 reductaseVariations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyCoupled motions direct electrons along human microsomal P450 ChainsKinetic and structural characterization of the interaction between the FMN binding domain of cytochrome P450 reductase and cytochrome c.Modulation of the cytochrome P450 reductase redox potential by the phospholipid bilayer.Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain.Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthaseDistinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains.Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins.Clinical, structural and functional implications of mutations and polymorphisms in human NADPH P450 oxidoreductase.Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.Dynamic control of electron transfers in diflavin reductases.Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase.Redox-linked domain movements in the catalytic cycle of cytochrome p450 reductase.Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency.Phosphorylation Controls Endothelial Nitric-oxide Synthase by Regulating Its Conformational Dynamics.Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4.The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain.Switching pyridine nucleotide specificity in P450 BM3: mechanistic analysis of the W1046H and W1046A enzymes.Inter-flavin electron transfer in cytochrome P450 reductase - effects of solvent and pH identify hidden complexity in mechanism.C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase.Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.
P2860
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P2860
Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Interflavin electron transfer ...... udies with coenzyme analogues.
@en
Interflavin electron transfer ...... udies with coenzyme analogues.
@nl
type
label
Interflavin electron transfer ...... udies with coenzyme analogues.
@en
Interflavin electron transfer ...... udies with coenzyme analogues.
@nl
prefLabel
Interflavin electron transfer ...... udies with coenzyme analogues.
@en
Interflavin electron transfer ...... udies with coenzyme analogues.
@nl
P2093
P2860
P1433
P1476
Interflavin electron transfer ...... udies with coenzyme analogues.
@en
P2093
Aldo Gutierrez
Alex Grunau
Andrew W Munro
C Roland Wolf
Nigel S Scrutton
P2860
P304
P356
10.1046/J.1432-1033.2003.03633.X
P407
P577
2003-06-01T00:00:00Z