Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme.
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Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signalExpression level and immunolocalization of de novo methyltransferase 3 protein (TuDNMT3) in adult females and males of the two-spotted spider mite, Tetranychus urticae.Mapping of protein-protein interaction sites by the 'absence of interference' approach.Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase.Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs.The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity.The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites.Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation.Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumorsDigging deep into "dirty" drugs - modulation of the methylation machinery.Inhibition of cancer cell proliferation by 5-fluoro-2'-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway.Mammalian DNA methyltransferases: a structural perspective.DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FAS ligand and RASSF1A.The promise and failures of epigenetic therapies for cancer treatmentCooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferaseAuto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue.Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.Enzymology of Mammalian DNA Methyltransferases.Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.Repeat-Induced Point Mutation and Other Genome Defense Mechanisms in FungiMtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.DNA methylation: A promising target for the twenty-first century
P2860
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P2860
Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Catalytic mechanism of DNA-
@nl
Catalytic mechanism of DNA-(cy ...... r by the murine Dnmt3a enzyme.
@en
type
label
Catalytic mechanism of DNA-
@nl
Catalytic mechanism of DNA-(cy ...... r by the murine Dnmt3a enzyme.
@en
prefLabel
Catalytic mechanism of DNA-
@nl
Catalytic mechanism of DNA-(cy ...... r by the murine Dnmt3a enzyme.
@en
P2093
P1476
Catalytic mechanism of DNA-(cy ...... r by the murine Dnmt3a enzyme.
@en
P2093
Humaira Gowher
Sabine Reither
P304
P356
10.1016/S0022-2836(03)00509-6
P407
P577
2003-06-01T00:00:00Z