Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.
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Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteinsRequirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells.Small RNAs establish delays and temporal thresholds in gene expressionInhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARARETRACTED: TGFβ1 signaling via αVβ6 integrinSignal processing in the TGF-beta superfamily ligand-receptor networkThe Role of microRNAs in the Diagnosis and Treatment of Pancreatic AdenocarcinomaCell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activationOAZ regulates bone morphogenetic protein signaling through Smad6 activationGatifloxacin induces S and G2-phase cell cycle arrest in pancreatic cancer cells via p21/p27/p53Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells.Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathwayZeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways.Dynamics of TGF-β/Smad signalingThe endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3.Plasticity of TGF-β signalingThiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance.Burst BMP triggered receptor kinase activity drives Smad1 mediated long-term target gene oscillation in C2C12 cellsPartial loss of Smad signaling during in vitro progression of HPV16-immortalized human keratinocytesCharacterization of negative feedback network motifs in the TGF-β signaling pathwayQuantitative analysis of transient and sustained transforming growth factor-β signaling dynamics.miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway.Regulation of Smad activities.Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer.Amniotic Membrane Modifies the Genetic Program Induced by TGFß, Stimulating Keratinocyte Proliferation and Migration in Chronic Wounds.Oleanolic acid induces migration in Mv1Lu and MDA-MB-231 epithelial cells involving EGF receptor and MAP kinases activation.Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals.Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching.The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor.A dynein motor attachment complex regulates TGFß/Smad3 signaling.Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesisTransforming growth factor beta depletion is the primary determinant of Smad signaling kineticsDecoding the quantitative nature of TGF-beta/Smad signaling.Quantitative modeling and analysis of the transforming growth factor beta signaling pathwayPathogenic mechanisms of pancreatitis.A Positive TGF-β/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer.Deregulated E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGFβ Signaling in Prostate Cancer.Latent effects of fibronectin, alpha5beta1 integrin, alphaVbeta5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion.TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function
P2860
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P2860
Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Attenuation of the TGF-beta-Sm ...... GF-beta-induced growth arrest.
@en
Attenuation of the TGF-beta-Sm ...... GF-beta-induced growth arrest.
@nl
type
label
Attenuation of the TGF-beta-Sm ...... GF-beta-induced growth arrest.
@en
Attenuation of the TGF-beta-Sm ...... GF-beta-induced growth arrest.
@nl
prefLabel
Attenuation of the TGF-beta-Sm ...... GF-beta-induced growth arrest.
@en
Attenuation of the TGF-beta-Sm ...... GF-beta-induced growth arrest.
@nl
P2860
P356
P1433
P1476
Attenuation of the TGF-beta-Sm ...... TGF-beta-induced growth arrest
@en
P2093
Francisco J Nicolás
P2860
P2888
P304
P356
10.1038/SJ.ONC.1206420
P407
P577
2003-06-01T00:00:00Z