Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.
about
Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.Comparison of male versus female responses in the Pig-a mutation assay.Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethaneEfficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.In Vivo Pig-a gene mutation assay: Guidance for 3Rs-friendly implementation.Comet assay in reconstructed 3D human epidermal skin models--investigation of intra- and inter-laboratory reproducibility with coded chemicals.Dose-Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU.Characterisation of an in vivo Pig-a gene mutation assay for use in regulatory toxicology studies.Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.
P2860
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P2860
Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Integration of Pig-a, micronuc ...... with 4-nitroquinoline-1-oxide.
@en
Integration of Pig-a, micronuc ...... with 4-nitroquinoline-1-oxide.
@nl
type
label
Integration of Pig-a, micronuc ...... with 4-nitroquinoline-1-oxide.
@en
Integration of Pig-a, micronuc ...... with 4-nitroquinoline-1-oxide.
@nl
prefLabel
Integration of Pig-a, micronuc ...... with 4-nitroquinoline-1-oxide.
@en
Integration of Pig-a, micronuc ...... with 4-nitroquinoline-1-oxide.
@nl
P2093
P2860
P356
P1476
Integration of Pig-a, micronuc ...... with 4-nitroquinoline-1-oxide.
@en
P2093
Ajit Thakur
Daniel J Roberts
Hemalatha Murli
Hepei Chen
Leon F Stankowski
Marie McKeon
Timothy Lawlor
P2860
P304
P356
10.1002/EM.20692
P577
2011-10-21T00:00:00Z