Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.
about
Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice.Predicting the future: opportunities and challenges for the chemical industry to apply 21st-century toxicity testing.Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.Comparison of male versus female responses in the Pig-a mutation assay.Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta™ Mouse.Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethaneEfficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.New and emerging technologies for genetic toxicity testing.How accurate is in vitro prediction of carcinogenicity?Need and potential value of the Pig-ain vivo mutation assay-a HESI perspective.Defining EMS and ENU dose-response relationships using the Pig-a mutation assay in ratsComparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.In Vivo Pig-a gene mutation assay: Guidance for 3Rs-friendly implementation.The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.Characterisation of an in vivo Pig-a gene mutation assay for use in regulatory toxicology studies.When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis.Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea.Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.Report on stage III Pig-a mutation assays using benzo[a]pyrene.Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes.Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate.Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a, micronucleus and Comet assays integrated into 28-day repeat dose studies.Risks for human health related to the presence of 3‐ and 2‐monochloropropanediol (MCPD), and their fatty acid esters, and glycidyl fatty acid esters in foodGlycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig-a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/- cells and the CD90.2 antigen.Evaluation of the in vivo mutagenicity of isopropyl methanesulfonate in acute and 28-day studies.Concurrent evaluation of general, immune, and genetic toxicity endpoints as part of an integrated testing strategy.Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 gpt delta rats.Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.The in vivo Pig-a gene mutation assay is useful for evaluating the genotoxicity of ionizing radiation in mice.No genotoxicity in rat blood cells upon 3- or 6-month inhalation exposure to CeO2 or BaSO4 nanomaterials.Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.
P2860
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P2860
Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Integration of mutation and ch ...... epeat dose toxicology studies.
@ast
Integration of mutation and ch ...... epeat dose toxicology studies.
@en
type
label
Integration of mutation and ch ...... epeat dose toxicology studies.
@ast
Integration of mutation and ch ...... epeat dose toxicology studies.
@en
prefLabel
Integration of mutation and ch ...... epeat dose toxicology studies.
@ast
Integration of mutation and ch ...... epeat dose toxicology studies.
@en
P2093
P2860
P356
P1476
Integration of mutation and ch ...... epeat dose toxicology studies.
@en
P2093
Dean Franklin
Dorothea K Torous
James Palis
James T MacGregor
Jeffrey C Bemis
Ollivier Hyrien
Pamela Weller
Souk Phonethepswath
Stephen D Dertinger
Steven M Bryce
P2860
P304
P356
10.1093/TOXSCI/KFQ070
P577
2010-03-04T00:00:00Z