Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.
about
Central role of the P2Y12 receptor in platelet activationInternational Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyMRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in miceP2X1 stimulation promotes thrombin receptor-mediated platelet aggregation.Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivoNanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.Characterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor.Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice.Thrombosis: Novel nanomedical concepts of diagnosis and treatmentEffects of P2Y(1) receptor antagonism on the reactivity of platelets from patients with stable coronary artery disease using aspirin and clopidogrelThe P2Y(1) receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice.Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor.Platelet receptor redox regulation.RhoG protein regulates platelet granule secretion and thrombus formation in mice.Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death.P2 receptors and platelet function.The P2Y1 receptor-mediated leukocyte adhesion to endothelial cells is inhibited by melatonin.Adenine triphosphate nucleotides are antagonists at the P2Y receptor.Calmodulin interacts with the platelet ADP receptor P2Y1Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation.The platelet P2Y receptors as targets for new antithrombotic drugs.4-Benzothiazole-7-hydroxyindolinyl diaryl ureas are potent P2Y1 antagonists with favorable pharmacokinetics: low clearance and small volume of distribution.
P2860
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P2860
Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
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2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
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2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Inhibition of localized thromb ...... 9, a P2Y1 receptor antagonist.
@en
Inhibition of localized thromb ...... 9, a P2Y1 receptor antagonist.
@nl
type
label
Inhibition of localized thromb ...... 9, a P2Y1 receptor antagonist.
@en
Inhibition of localized thromb ...... 9, a P2Y1 receptor antagonist.
@nl
prefLabel
Inhibition of localized thromb ...... 9, a P2Y1 receptor antagonist.
@en
Inhibition of localized thromb ...... 9, a P2Y1 receptor antagonist.
@nl
P2093
P2860
P1476
Inhibition of localized thromb ...... 79, a P2Y1 receptor antagonist
@en
P2093
P2860
P304
P356
10.1046/J.1538-7836.2003.00144.X
P577
2003-06-01T00:00:00Z