Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme.
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Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosomeManipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicityMechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of Saccharomyces cerevisiae Glutamate Cysteine LigaseRegulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomesThe glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmissionImplications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and ArtemisininGenetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei.Dissecting the role of glutathione biosynthesis in Plasmodium falciparum.Degrees of chloroquine resistance in Plasmodium - is the redox system involved?Evaluation of Antigens for Development of a Serological Test for Human African TrypanosomiasisThe silicon trypanosome: a test case of iterative model extension in systems biology.Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux.RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.Trypanocidal drugs: mechanisms, resistance and new targets.State of the art in African trypanosome drug discovery.Role and Regulation of Glutathione Metabolism in Plasmodium falciparum.In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.Biochemical and biophysical characterization of Leishmania donovani gamma-glutamylcysteine synthetaseDissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modelingThe gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants.Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi.Expression Differences of Resistance-Related Genes Induced by Cycloxaprid Using qRT-PCR in the Female Adult of Sogatella furcifera (Hemiptera: Delphacidae).Drug target validation of the trypanothione pathway enzymes through metabolic modelling.Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione
P2860
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P2860
Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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name
Gene knockdown of gamma-glutam ...... hat it is an essential enzyme.
@en
Gene knockdown of gamma-glutam ...... hat it is an essential enzyme.
@nl
type
label
Gene knockdown of gamma-glutam ...... hat it is an essential enzyme.
@en
Gene knockdown of gamma-glutam ...... hat it is an essential enzyme.
@nl
prefLabel
Gene knockdown of gamma-glutam ...... hat it is an essential enzyme.
@en
Gene knockdown of gamma-glutam ...... hat it is an essential enzyme.
@nl
P2093
P356
P1476
Gene knockdown of gamma-glutam ...... hat it is an essential enzyme.
@en
P2093
Margaret A Harmon
Margaret A Phillips
Tu T Huynh
Van T Huynh
P304
39794-39800
P356
10.1074/JBC.M306306200
P407
P577
2003-07-29T00:00:00Z