Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
about
Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activityAlphavirus RNA synthesis and non-structural protein functionsRole of the Amphipathic Peptide of Semliki Forest Virus Replicase Protein nsP1 in Membrane Association and Virus ReplicationEnzymatic Defects of the nsP2 Proteins of Semliki Forest Virus Temperature-Sensitive MutantsDevelopment of Sindbis Viruses Encoding nsP2/GFP Chimeric Proteins and Their Application for Studying nsP2 FunctioningMolecular cloning, overproduction, purification and biochemical characterization of the p39 nsp2 protease domains encoded by three alphavirusesStructural and functional insights into alphavirus polyprotein processing and pathogenesisKinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine ProteaseNTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 proteinThe role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses.Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcriptionNovel functions of the alphavirus nonstructural protein nsP3 C-terminal region.Structural basis for substrate specificity of alphavirus nsP2 proteases.RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replicationAssembly of alphavirus replication complexes from RNA and protein components in a novel trans-replication system in mammalian cells.Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3.Semliki Forest virus nonstructural protein 2 is involved in suppression of the type I interferon response.Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein.Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine.Purification, crystallization and X-ray diffraction analysis of the C-terminal protease domain of Venezuelan equine encephalitis virus nsP2Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis.Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virusViral precursor polyproteins: keys of regulation from replication to maturationA Novel Mechanism Underlying the Innate Immune Response Induction upon Viral-Dependent Replication of Host Cell mRNA: A Mistake of +sRNA Viruses' Replicases.Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions.Properties of non-structural protein 1 of Semliki Forest virus and its interference with virus replicationMacromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein.Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template.Discovery of Novel Peptidomimetics as Irreversible CHIKV NsP2 Protease Inhibitors Using Quantum Mechanical-Based Ligand Descriptors.Adaptation of Venezuelan equine encephalitis virus lacking 51-nt conserved sequence element to replication in mammalian and mosquito cells.Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis.Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins.Polyprotein Processing as a Determinant for in Vitro Activity of Semliki Forest Virus Replicase.Molecular determinants of substrate specificity for Semliki Forest virus nonstructural protease.Characterization of the cysteine protease domain of Semliki Forest virus replicase protein nsP2 by in vitro mutagenesis.Nonstructural Proteins of Alphavirus-Potential Targets for Drug Development.A Chikungunya virus trans-replicase system reveals the importance of delayed non-structural polyprotein processing for efficient replication complex formation in mosquito cells.
P2860
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P2860
Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
@en
Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
@nl
type
label
Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
@en
Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
@nl
prefLabel
Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
@en
Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
@nl
P2860
P50
P356
P1476
Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
@en
P2093
Andrey Golubtsov
Valeria Sizemskaja
P2860
P304
41636-41645
P356
10.1074/JBC.M307481200
P407
P577
2003-08-12T00:00:00Z