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Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tauEndogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.Genetic risk factors in Alzheimer's diseaseLDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis.Association between presenilin-1 Glu318Gly mutation and familial Alzheimer's disease in the Australian population.The multiple paradoxes of presenilins.Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapyDisease-related mutations among Caribbean Hispanics with familial dementia.The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans.The link between apolipoprotein E, presenilin 1, and kinesin light chain 1 gene polymorphisms and age-related cortical cataracts in the Chinese population.Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brainIn situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brainChromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene.Evidence for phosphorylation and oligomeric assembly of presenilin 1.Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.Network-wide dysregulation of calcium homeostasis in Alzheimer's disease.BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein.Recent advances in the genetics of Alzheimer's disease and vascular dementia with an emphasis on gene-environment interactions.Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant.Cellular and molecular neurosurgery: pathways from concept to reality--part I: target disorders and concept approaches to gene therapy of the central nervous system.Structure nor stability of the transmembrane spanning 6/7 domain of presenilin I correlates with pathogenicity.Novel proline endopeptidase inhibitors do not modify Abeta40/42 formation and degradation by human cells expressing wild-type and swedish mutated beta-amyloid precursor protein.The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart.Risk factors and Alzheimer's disease: a comparative study of two communities.Reply to niermeijer.The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo.Conditionally targeted deletion of PSEN1 leads to diastolic heart dysfunction.Neurons and extracellular neurofibrillary tangles in the hippocampal subdivisions in early-onset familial Alzheimer's disease: a case study.Quantification of presenilin-1 mRNA in Alzheimer's disease brains.Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.Immunohistochemical analysis of presenilin-1 expression in the mouse brain.Novel intronic polymorphisms in the presenilin-2 gene and a case-control association study of Alzheimer's disease.Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.The presenilin genes: a new gene family involved in Alzheimer disease pathologyLinkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2Splicing mutation of presenilin-1 gene for early-onset familial Alzheimer's disease
P2860
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P2860
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Presenilins and Alzheimer disease.
@en
Presenilins and Alzheimer disease.
@nl
type
label
Presenilins and Alzheimer disease.
@en
Presenilins and Alzheimer disease.
@nl
prefLabel
Presenilins and Alzheimer disease.
@en
Presenilins and Alzheimer disease.
@nl
P2860
P356
P1433
P1476
Presenilins and Alzheimer disease.
@en
P2093
Van Broeckhoven C
P2860
P2888
P304
P356
10.1038/NG1195-230
P407
P577
1995-11-01T00:00:00Z