Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseaseSyntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionThe presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residueInteraction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell deathNeurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutationProfiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamusMice lacking both presenilin genes exhibit early embryonic patterning defectsPresenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membraneDifferential release of β-amyloid from dendrite- versus axon-targeted APP.Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.The regulation of presenilin-1 by nerve growth factor.Alphaviruses as tools in neurobiology and gene therapy.The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells.TRPC channels and their implication in neurological diseasesThe PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila modelPresenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologicallyCalbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial functionGenetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.Large scale transient 5-HT3 receptor production with the Semliki Forest Virus Expression System.Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture.Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells.Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin miceNegative regulation of the SAPK/JNK signaling pathway by presenilin 1Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing.C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasomeProteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.Cell surface expression of the Alzheimer disease-related presenilin proteins.Evidence for phosphorylation and oligomeric assembly of presenilin 1.Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disordersTRPC Channels: Prominent Candidates of Underlying Mechanism in Neuropsychiatric Diseases.Fleshing out the amyloid cascade hypothesis: the molecular biology of Alzheimer's disease.Role of Endoplasmic Reticulum Stress and Unfolded Protein Responses in Health and DiseasesEndoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.
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Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Expression and analysis of pre ...... in cell bodies and dendrites.
@en
Expression and analysis of pre ...... in cell bodies and dendrites.
@nl
type
label
Expression and analysis of pre ...... in cell bodies and dendrites.
@en
Expression and analysis of pre ...... in cell bodies and dendrites.
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prefLabel
Expression and analysis of pre ...... in cell bodies and dendrites.
@en
Expression and analysis of pre ...... in cell bodies and dendrites.
@nl
P2093
P2860
P356
P1476
Expression and analysis of pre ...... in cell bodies and dendrites.
@en
P2093
B S Wojczyk
J Q Trojanowski
K M Felsenstein
P2860
P304
P356
10.1073/PNAS.93.17.9223
P407
P577
1996-08-01T00:00:00Z