Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

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http://www.wikidata.org/entity/Q44643522
Role of dichloroacetate in the treatment of genetic mitochondrial diseasesPhysiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats.Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?The heme precursor delta-aminolevulinate blocks peripheral myelin formation.Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in childrenKey issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesisChloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice.A Mechanism-Based Pharmacokinetic Enzyme Turnover Model for Dichloroacetic Acid Autoinhibition in Rats.Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study.
P2860

Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

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http://www.wikidata.org/entity/Q44643522
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2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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Pharmacologic or genetic ablat ...... rosine catabolites in rodents.
@en
Pharmacologic or genetic ablat ...... rosine catabolites in rodents.
@nl
type
label
Pharmacologic or genetic ablat ...... rosine catabolites in rodents.
@en
Pharmacologic or genetic ablat ...... rosine catabolites in rodents.
@nl
prefLabel
Pharmacologic or genetic ablat ...... rosine catabolites in rodents.
@en
Pharmacologic or genetic ablat ...... rosine catabolites in rodents.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Pharmacologic or genetic ablat ...... rosine catabolites in rodents.
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698