Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation.

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Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexes Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard.Highly efficient fluorescent interstrand photo-crosslinking of DNA duplexes labeled with 5-fluoro-4-thio-2'-o-methyluridine.

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Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation.

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2012 nî lūn-bûn

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Inter- and intrastrand DNA cro ...... hemistry and drug orientation.

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Inter- and intrastrand DNA cro ...... hemistry and drug orientation.

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Inter- and intrastrand DNA cro ...... hemistry and drug orientation.

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Inter- and intrastrand DNA cro ...... hemistry and drug orientation.

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Ahmed Kamal

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Jenny Seifert

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Klaus Weisz

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Soheil Pezeshki

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P2860

Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization

Solution structure of a covalently bound pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex

NMR structural studies on the covalent DNA binding of a pyrrolobenzodiazepine-naphthalimide conjugate

Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity

DNA minor groove recognition by bis-benzimidazole analogues of Hoechst 33258: insights into structure-DNA affinity relationships assessed by fluorescence titration measurements.

An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences.

A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors

Observation of a single-stranded DNA/pyrrolobenzodiazepine adduct.

Recent developments in the design, synthesis and structure-activity relationship studies of pyrrolo[2,1-c][1,4]benzodiazepines as DNA-interactive antitumour antibiotics.

DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents

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Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation.

about

P2860

P2860

Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation.

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