Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity
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Stereochemistry Modulates the Stability of Reduced Interstrand Cross-Links Arising from R - and S -α-CH 3 -γ-OH-1, N 2 -Propano-2‘-deoxyguanosine in the 5‘-CpG-3‘ DNA Sequence †Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexesCovalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA FragmentsDissociation of minor groove binders from DNA: insights from metadynamics simulations.Aminobenzoates as building blocks for natural product assembly lines.Development of distamycin-related DNA binding anticancer drugs.Identification of the dioxygenase-generated intermediate formed during biosynthesis of the dihydropyrrole moiety common to anthramycin and sibiromycinChemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA.PCR-based development of DNA substrates containing modified bases: an efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins.Mutasynthesis of a potent anticancer sibiromycin analogueModeling anticancer drug-DNA interactions via mixed QM/MM molecular dynamics simulations.Biosynthesis of sibiromycin, a potent antitumor antibiotic.From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepinesAtomistic-level portrayal of drug-DNA Interplay: a history of courtships and meetings revealed by molecular simulations.Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent.DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor AgentsTime-resolved fluorescence studies of tomaymycin bonding to synthetic DNAsSliding of alkylating anticancer drugs along the minor groove of DNA: new insights on sequence selectivity1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity.Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation.The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis.Novel pathway of 3-hydroxyanthranilic acid formation in limazepine biosynthesis reveals evolutionary relation between phenazines and pyrrolobenzodiazepines.
P2860
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P2860
Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity
description
1994 nî lūn-bûn
@nan
1994 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Crystal structure of a covalen ...... lar explanation of specificity
@ast
Crystal structure of a covalen ...... lar explanation of specificity
@en
Crystal structure of a covalen ...... lar explanation of specificity
@nl
type
label
Crystal structure of a covalen ...... lar explanation of specificity
@ast
Crystal structure of a covalen ...... lar explanation of specificity
@en
Crystal structure of a covalen ...... lar explanation of specificity
@nl
prefLabel
Crystal structure of a covalen ...... lar explanation of specificity
@ast
Crystal structure of a covalen ...... lar explanation of specificity
@en
Crystal structure of a covalen ...... lar explanation of specificity
@nl
P2093
P3181
P356
P1433
P1476
Crystal structure of a covalen ...... lar explanation of specificity
@en
P2093
D S Goodsell
I Baikalov
K Grzeskowiak
R E Dickerson
P304
P3181
P356
10.1021/BI00250A011
P407
P577
1994-11-22T00:00:00Z