Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2).
about
Pyruvate kinase M2 at a glanceCombining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activityActivators of PKM2 in cancer metabolism.PKM2 and cancer: The function of PKM2 beyond glycolysis.Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.In vitro effects of some flavones on human pyruvate kinase isoenzyme M2.Pyrazole synthesis via a cascade Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones.Pyruvate kinase activators as a therapy target: a patent review 2011-2017.
P2860
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P2860
Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2).
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
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2013年學術文章
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2013年學術文章
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name
Discovery of 3-
@nl
Discovery of 3-(trifluoromethy ...... orm of pyruvate kinase (PKM2).
@en
type
label
Discovery of 3-
@nl
Discovery of 3-(trifluoromethy ...... orm of pyruvate kinase (PKM2).
@en
prefLabel
Discovery of 3-
@nl
Discovery of 3-(trifluoromethy ...... orm of pyruvate kinase (PKM2).
@en
P2093
P1476
Discovery of 3-(trifluoromethy ...... form of pyruvate kinase (PKM2)
@en
P2093
Adrianne Clifford
Jeremy Bullough
K Mark Parnell
Kevin Wright
Koc-Kan Ho
Michael Saunders
Michael V McCullar
Rebecca N Nix
Scott Pearce
Steven B Kanner
P304
P356
10.1016/J.BMCL.2013.12.028
P407
P577
2013-12-17T00:00:00Z