Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels. - Wikidata - awgldk - TriplyDB

Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels.

Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels.

http://www.wikidata.org/entity/Q44697518

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Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2 Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease 4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases.Nrf2 activation protects the liver from ischemia/reperfusion injury in mice Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype.RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy.Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner.The Nrf2-ARE cytoprotective pathway in astrocytes.Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo.PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice Reduction-responsive dithiomaleimide-based nanomedicine with high drug loading and FRET-indicated drug release Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies.Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia.Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance.Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease.The NRF2 activation and antioxidative response are not impaired overall during hyperoxia-induced lung epithelial cell death Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.Glutathione in cancer cell death Redox regulation of cell survival The antioxidant response element and oxidative stress modifiers in airway diseases.Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin The emerging role of the Nrf2-Keap1 signaling pathway in cancer Behavioral effects of developmental methylmercury drinking water exposure in rodents Cytochrome P450-mediated pulmonary metabolism of carcinogens: regulation and cross-talk in lung carcinogenesis.Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.Slow regulated release of H2S inhibits oxidative stress induced cell death by influencing certain key signaling molecules.Cloning and characterization of the human glutathione synthetase 5'-flanking region MicroRNA-125b-5p mimic inhibits acute liver failure.Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants.A hot water extract of turmeric (Curcuma longa) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production.NF-E2-related factor 2 activation in PC12 cells: its protective role in manganese-induced damage.In vitro interactions of thallium with components of the glutathione-dependent antioxidant defence system.Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation.

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Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels.

http://www.wikidata.org/entity/Q44697518

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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name

Nrf2 regulates the sensitivity ...... racellular glutathione levels.

@en

Nrf2 regulates the sensitivity ...... racellular glutathione levels.

@nl

type

label

Nrf2 regulates the sensitivity ...... racellular glutathione levels.

@en

Nrf2 regulates the sensitivity ...... racellular glutathione levels.

@nl

prefLabel

Nrf2 regulates the sensitivity ...... racellular glutathione levels.

@en

Nrf2 regulates the sensitivity ...... racellular glutathione levels.

@nl

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Nrf2 regulates the sensitivity ...... racellular glutathione levels.

@en

P2093

Aki Hirayama

http://www.w3.org/2001/XMLSchema#string

Akio Koyama

http://www.w3.org/2001/XMLSchema#string

Keigyou Yoh

http://www.w3.org/2001/XMLSchema#string

Ken Itoh

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Naoki Morito

http://www.w3.org/2001/XMLSchema#string

Satoru Takahashi

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Apoptosis by death factor

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

CD95-Mediated murine hepatic apoptosis requires an intact glutathione status

Caspases: enemies within

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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9275-9281

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scholarly article

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10.1038/SJ.ONC.1207024

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58

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22

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2003-12-01T00:00:00Z

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8953489

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14681686

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