Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
about
Klotho and agingRegulation of renal outer medullary potassium channel and renal K(+) excretion by KlothoMolecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily membersKlotho in cardiovascular disease: Current and future perspectivesBiological Role of Anti-aging Protein KlothoKlotho, stem cells, and agingRegulation and function of the FGF23/klotho endocrine pathwaysCalcium and phosphate impact cardiovascular risk.Regulation of lysosomal ion homeostasis by channels and transportersFGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosisFGF23 promotes renal calcium reabsorption through the TRPV5 channelN-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse modelsFibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolismAssociations of FGF-23 and sKlotho with cardiovascular outcomes among patients with CKD stages 2-4Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology.Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity.Klotho deficiency causes vascular calcification in chronic kidney disease.Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.The cooperation of FGF receptor and Klotho is involved in excretory canal development and regulation of metabolic homeostasis in Caenorhabditis elegans.Implications of Klotho in vascular health and disease.Klotho and the aging processRole of Klotho in aging, phosphate metabolism, and CKD.Molecular basis of Klotho: from gene to function in agingKlotho and kidney disease.Antiaging gene Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 β-cellsTumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis.The Role and Mechanism of α-Klotho in the Calcification of Rat Aortic Vascular Smooth Muscle Cells.Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes.Renal Production, Uptake, and Handling of Circulating αKlothoTreatment of phosphate retention: The earlier the better?Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis.A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidismRenal and extrarenal actions of Klotho.Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1The role of fibroblast growth factor 23 and Klotho in uremic cardiomyopathy.The role of Klotho in energy metabolism.Klotho as a regulator of oxidative stress and senescence.Current understanding of klotho.Secreted klotho and chronic kidney disease
P2860
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P2860
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
@en
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
@nl
type
label
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
@en
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
@nl
prefLabel
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
@en
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
@nl
P2093
P356
P1476
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
@en
P2093
Akihiro Imura
Akiko Iwano
Jean-Noël Freund
Osamu Tohyama
Yo-ichi Nabeshima
P304
P356
10.1074/JBC.M312392200
P407
P577
2003-12-29T00:00:00Z