A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain. - Wikidata - awgldk - TriplyDB

A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain.

A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain.

http://www.wikidata.org/entity/Q44711807

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Niemann-Pick disease type C Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brain Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysins A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations.Assessing cholesterol storage in live cells and C. elegans by stimulated Raman scattering imaging of phenyl-Diyne cholesterol.The factors affecting lipid profile in adult patients with Mucopolysaccharidosis Multi-system disorders of glycosphingolipid and ganglioside metabolism Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis.A marked paucity of granule cells in the developing cerebellum of the Npc1(-/-) mouse is corrected by a single injection of hydroxypropyl-β-cyclodextrin Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1)Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect.Niemann-Pick type C disease and intracellular cholesterol trafficking.Plasticity in membrane cholesterol contributes toward electrical maturation of hearing.Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation.GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice.Endosomal/lysosomal processing of gangliosides affects neuronal cholesterol sequestration in Niemann-Pick disease type C.Characterisation of detergent-insoluble membranes in pollen tubes of Nicotiana tabacum (L.).Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease Secondary lipid accumulation in lysosomal disease.Cholesterol metabolism and homeostasis in the brain A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele.Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration.Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1-/- mouse brain.Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation.Altered lipid metabolism in brain injury and disorders.Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain.Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.Cholesterol in Niemann-Pick Type C disease.Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O.Defective cholesterol trafficking in Niemann-Pick C-deficient cells.Complex lipid trafficking in Niemann-Pick disease type C.Trypanosoma cruzi infection results in an increase in intracellular cholesterol.Cellular Cholesterol Homeostasis in Alzheimer's Disease.Generation of a human neuronal stable cell model for niemann-pick C disease by RNA interference.Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein.

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P2860

A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain.

http://www.wikidata.org/entity/Q44711807

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

A novel cholesterol stain reve ...... mann-Pick type C1 mouse brain.

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A novel cholesterol stain reve ...... mann-Pick type C1 mouse brain.

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type

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A novel cholesterol stain reve ...... mann-Pick type C1 mouse brain.

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A novel cholesterol stain reve ...... mann-Pick type C1 mouse brain.

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A novel cholesterol stain reve ...... mann-Pick type C1 mouse brain.

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A novel cholesterol stain reve ...... mann-Pick type C1 mouse brain.

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Journal of Lipid Research

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A novel cholesterol stain reve ...... mann-Pick type C1 mouse brain.

@en

P2093

Naomi Sakashita

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Patrick C Reid

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Shigeki Sugii

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William F Hickey

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Yoshiko Ohno-Iwashita

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Yukiko Shimada

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P2860

Identification of HE1 as the second gene of Niemann-Pick C disease

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease

Functional rafts in cell membranes

Transmembrane molecular pump activity of Niemann-Pick C1 protein

Functions of lipid rafts in biological membranes

The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.

Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations.

Lipid changes in Niemann-Pick disease type C brain: personal experience and review of the literature.

The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo.

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582-591

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10.1194/JLR.D300032-JLR200

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3

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45

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