LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration - Wikidata - awgldk - TriplyDB

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

http://www.wikidata.org/entity/Q24671948

about

The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering Virological and cellular roles of the transcriptional coactivator LEDGF/p75 Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity Epigenetic control of HIV-1 post integration latency: implications for therapy Impact of Chromatin on HIV Replication Structural basis for functional tetramerization of lentiviral integrase Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation DNA minicircles clarify the specific role of DNA structure on retroviral integration p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes Allosteric Inhibition of Human Immunodeficiency Virus Integrase Functional and structural characterization of the integrase from the prototype foamy virus A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75 Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction A new class of multimerization selective inhibitors of HIV-1 integrase Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain Retroviral Integrase: Then and Now Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain Retroviral DNA Integration Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.Measuring rapid hydrogen exchange in the homodimeric 36 kDa HIV-1 integrase catalytic core domain LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity The Integrator complex controls the termination of transcription at diverse classes of gene targets.Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 Is critical for HIV-1 infection.Molecular modeling study on the allosteric inhibition mechanism of HIV-1 integrase by LEDGF/p75 binding site inhibitors.Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM/TSP The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

http://www.wikidata.org/entity/Q24671948

description

2007 nî lūn-bûn

@nan

2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2007年の論文

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2007年学术文章

@wuu

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

@zh-my

2007年学术文章

@zh-sg

2007年學術文章

@yue

name

LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

@ast

LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

@en

LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

@nl

type

label

LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

@ast

LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

@en

LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

@nl

prefLabel

LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

@ast

LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

@en

LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

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Genes & Development

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LEDGF/p75 functions downstream ...... ene-specific HIV-1 integration

@en

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Alan Engelman

http://www.w3.org/2001/XMLSchema#string

Janet E Daigle

http://www.w3.org/2001/XMLSchema#string

Ming-Chieh Shun

http://www.w3.org/2001/XMLSchema#string

Nick Vandegraaff

http://www.w3.org/2001/XMLSchema#string

Nidhanapati K Raghavendra

http://www.w3.org/2001/XMLSchema#string

Siobhan Hughes

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus

Tudor, MBT and chromo domains gauge the degree of lysine methylation

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

Degradation of HIV-1 integrase by the N-end rule pathway

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

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1767-78

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scholarly article

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1636997

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10.1101/GAD.1565107

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14

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21

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Peter Cherepanov

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2007-07-15T00:00:00Z

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6199664

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17639082

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1920171

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