Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
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Interaction of integrin β4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancementCrystal structure of a lipid G protein-coupled receptorRequirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interferenceFTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacologySphingosine 1-phosphate receptor modulators in multiple sclerosisSphingosine 1-phosphate receptor agonists: a patent review (2010-2012)FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosisCharacterization of isoenzyme-selective inhibitors of human sphingosine kinasesThe clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in ratSphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate.Characterization of a sphingosine 1-phosphate receptor antagonist prodrugSphingosine 1-phosphate chemical biologyInternational Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist.Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.Cardiac effects of amiselimod compared with fingolimod and placebo: results of a randomised, parallel-group, phase I study in healthy subjects.Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MSDiscovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate.The differential effects of FTY720 on functional recovery and infarct size following myocardial ischaemia/reperfusion.Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosisSphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.An update on the biology of sphingosine 1-phosphate receptors.Fingolimod and cardiac risk: latest findings and clinical implicationsExtracellular and intracellular actions of sphingosine-1-phosphateASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profileAttacking the supply wagons to starve cancer cells to death.Circulating sphingolipid biomarkers in models of type 1 diabetes.(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional AntagonistsDesensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulatorDiscovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites.Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs.
P2860
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P2860
Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Immune cell regulation and car ...... ia distinct receptor subtypes.
@en
Immune cell regulation and car ...... ia distinct receptor subtypes.
@nl
type
label
Immune cell regulation and car ...... ia distinct receptor subtypes.
@en
Immune cell regulation and car ...... ia distinct receptor subtypes.
@nl
prefLabel
Immune cell regulation and car ...... ia distinct receptor subtypes.
@en
Immune cell regulation and car ...... ia distinct receptor subtypes.
@nl
P2093
P356
P1476
Immune cell regulation and car ...... via distinct receptor subtypes
@en
P2093
Bergstrom J
Milligan J
P304
P356
10.1124/JPET.103.062828
P407
P577
2004-01-27T00:00:00Z