about
Restructuring of the dinucleotide-binding fold in an NADP(H) sensor proteinCrystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor designN-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptorsA Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR DimerizationThe RGD finger of Del-1 is a unique structural feature critical for integrin bindingCEACAM1 regulates TIM-3-mediated tolerance and exhaustionMechanism of microtubule stabilization by taccalonolide AJ.Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognitionPironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubuleDiscovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations.Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1.Protein production, crystallization and preliminary X-ray analysis of two isoforms of the Dscam1 Ig7 domain.[Cloning, expression and characterization of the hypoxanthine-guanine phosphoribosyltransferase mutants from T. tengcongensis].Cloning, purification, and characterization of thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis.Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis.Soluble expression, purification, and stabilization of a pro-apoptotic human protein, CARP.Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design.A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance.Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design.Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development.((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.Protein preparation, crystallization and preliminary X-ray crystallographic studies of a thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis.[Production and stabilization of an integrin-binding moiety of complement component 3].A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in TumorsParallel cloning, expression, purification and crystallization of human proteins for structural genomicsX-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cellsReversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicityStructure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-β-lactamasesA novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding modeStructural insights into the design of indole derivatives as tubulin polymerization inhibitors
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P50
description
researcher ORCID: 0000-0002-2398-4482
@en
name
Qiang Chen
@ast
Qiang Chen
@en
Qiang Chen
@es
Qiang Chen
@nl
Qiang Chen
@sl
type
label
Qiang Chen
@ast
Qiang Chen
@en
Qiang Chen
@es
Qiang Chen
@nl
Qiang Chen
@sl
prefLabel
Qiang Chen
@ast
Qiang Chen
@en
Qiang Chen
@es
Qiang Chen
@nl
Qiang Chen
@sl
P1053
M-1630-2016
P106
P31
P3829
P496
0000-0002-2398-4482