Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

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Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

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Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

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Item

label

Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

@en

Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

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Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

@en

Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

@nl

P1476

Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors

@en

P2093

Hua-Li Wang

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Li Jing

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Ling-Ling Yang

http://www.w3.org/2001/XMLSchema#string

Sen Ji

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Sha Liu

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Wei-Jian Li

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Xu Cheng

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Yamei Yu

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Zhu-Jun Yu

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P2860

Open Babel: An open chemical toolbox

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

High-throughput assays for promiscuous inhibitors.

P304

257-268

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P31

scholarly article

P356

10.1111/CBDD.13077

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Qiang Chen

Guo-Bo Li

Yong Wu

P577

2017-08-18T00:00:00Z

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P698

28756638

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