Metabolism of P2 receptor agonists in human airways: implications for mucociliary clearance and cystic fibrosis.
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International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyAdenosine A2B Receptor: From Cell Biology to Human DiseasesP2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory painAlterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosisAirway wall stiffening increases peak wall shear stress: a fluid-structure interaction study in rigid and compliant airways.Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cellsCellular function and molecular structure of ecto-nucleotidases.Physiological regulation of ATP release at the apical surface of human airway epitheliaNucleotide release provides a mechanism for airway surface liquid homeostasisActivation of the transcription factor FosB/activating protein-1 (AP-1) is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells.Purinergic regulation of duodenal surface pH and ATP concentration: implications for mucosal defence, lipid uptake and cystic fibrosisEbselen is a potent non-competitive inhibitor of extracellular nucleoside diphosphokinaseElevated airway purines in COPD.Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection.Purine receptors: GPCR structure and agonist designE-NTPDases in human airways: Regulation and relevance for chronic lung diseasesSoluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia.NADPH oxidases in lung biology and pathology: host defense enzymes, and more.Liquid movement across the surface epithelium of large airwaysCoupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling.Modulation of purinergic signaling by NPP-type ectophosphodiesterases.Regulation of cellular ATP releaseExtracellular purines are biomarkers of neutrophilic airway inflammation.Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways.UDP-glucose promotes neutrophil recruitment in the lung.Inflammation promotes airway epithelial ATP release via calcium-dependent vesicular pathways.Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases.New pulmonary therapies directed at targets other than CFTR.Airway gas flow.Structure and function of the mucus clearance system of the lung.Apical adenosine regulates basolateral Ca2+-activated potassium channels in human airway Calu-3 epithelial cells.Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia.Mathematical model of nucleotide regulation on airway epithelia. Implications for airway homeostasis.Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile.Quantification of periciliary fluid height in human airway biopsies is feasible, but not suitable as a biomarker.Responses of differentiated primary human lung epithelial cells to exposure to diesel exhaust at an air-liquid interface.
P2860
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P2860
Metabolism of P2 receptor agonists in human airways: implications for mucociliary clearance and cystic fibrosis.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Metabolism of P2 receptor agon ...... clearance and cystic fibrosis.
@en
Metabolism of P2 receptor agon ...... clearance and cystic fibrosis.
@nl
type
label
Metabolism of P2 receptor agon ...... clearance and cystic fibrosis.
@en
Metabolism of P2 receptor agon ...... clearance and cystic fibrosis.
@nl
prefLabel
Metabolism of P2 receptor agon ...... clearance and cystic fibrosis.
@en
Metabolism of P2 receptor agon ...... clearance and cystic fibrosis.
@nl
P2093
P2860
P356
P1476
Metabolism of P2 receptor agon ...... clearance and cystic fibrosis.
@en
P2093
Lauranell H Burch
Maryse Picher
Richard C Boucher
P2860
P304
20234-20241
P356
10.1074/JBC.M400305200
P407
P577
2004-03-01T00:00:00Z