Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants.
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Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infectionsCrystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of SchistosomiasisLocal suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasisAn Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage InvasionSystems analysis of metabolism in the pathogenic trypanosomatid Leishmania majorAge-related alteration of arginase activity impacts on severity of leishmaniasisTranscriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes.Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis.Modulation of the arginase pathway in the context of microbial pathogenesis: a metabolic enzyme moonlighting as an immune modulatorResistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation with antimony therapy and TNF-alpha production.Genetically modified organisms and visceral leishmaniasisMAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana.BALB/c mice deficient in CD4 T cell IL-4Rα expression control Leishmania mexicana Load although female but not male mice develop a healer phenotypeThe N-terminal domain and glycosomal localization of Leishmania initial acyltransferase LmDAT are important for lipophosphoglycan synthesisAxenic Leishmania amazonensis promastigotes sense both the external and internal arginine pool distinctly regulating the two transporter-coding genes.Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity.Insulin-like growth factor-I induces arginase activity in Leishmania amazonensis amastigote-infected macrophages through a cytokine-independent mechanism.Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infectionInhibition profile of Leishmania mexicana arginase reveals differences with human arginase I.Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infectionGenerating knock-in parasites: integration of an ornithine decarboxylase transgene into its chromosomal locus in Leishmania donovaniCrystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection.Inhibition of Leishmania (Leishmania) amazonensis and rat arginases by green tea EGCG, (+)-catechin and (-)-epicatechin: a comparative structural analysis of enzyme-inhibitor interactions.Nutrient transport and pathogenesis in selected parasitic protozoa.Spermidine synthase is required for virulence of Leishmania donovani.The genetic toolbox for Leishmania parasitesL-arginine and cationic amino acid transporter 2B regulate growth and survival of Leishmania amazonensis amastigotes in macrophages.Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice.LC-MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes.Validation of spermidine synthase as a drug target in African trypanosomes.Multifactorial etiology of gastric cancerCrystal structures of Leishmania mexicana arginase complexed with α,α-disubstituted boronic amino-acid inhibitors.L-arginine metabolism and its impact on host immunity against Leishmania infectionLeishmania donovani ornithine decarboxylase is indispensable for parasite survival in the mammalian host.Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.Arginine homeostasis and transport in the human pathogen Leishmania donovani.Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes.Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism.
P2860
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P2860
Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants.
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2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
Arginase plays a pivotal role ...... tion of gene deletion mutants.
@en
Arginase plays a pivotal role ...... tion of gene deletion mutants.
@nl
type
label
Arginase plays a pivotal role ...... tion of gene deletion mutants.
@en
Arginase plays a pivotal role ...... tion of gene deletion mutants.
@nl
prefLabel
Arginase plays a pivotal role ...... tion of gene deletion mutants.
@en
Arginase plays a pivotal role ...... tion of gene deletion mutants.
@nl
P2093
P356
P1476
Arginase plays a pivotal role ...... tion of gene deletion mutants.
@en
P2093
Buddy Ullman
K Michael Gibson
Michael J Tancer
Michelle R Polinsky
Sigrid C Roberts
P304
23668-23678
P356
10.1074/JBC.M402042200
P407
P577
2004-03-15T00:00:00Z