Validation of spermidine synthase as a drug target in African trypanosomes.
about
Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomesMathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identificationIdentification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic TrypanosomatidsPolyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilitiesMechanistic insights into the dual inhibition strategy for checking Leishmaniasis.Target validation: linking target and chemical properties to desired product profileIn-silico gene co-expression network analysis in Paracoccidioides brasiliensis with reference to haloacid dehalogenase superfamily hydrolase gene.RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme.Trypanocidal drugs: mechanisms, resistance and new targets.State of the art in African trypanosome drug discovery.Development of novel drugs for human African trypanosomiasis.Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.In vitro antileishmanial, trypanocidal, and Mammalian cell activities of diverse n,n' -dihetaryl substituted diamines and related compounds.In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.
P2860
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P2860
Validation of spermidine synthase as a drug target in African trypanosomes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Validation of spermidine synthase as a drug target in African trypanosomes.
@ast
Validation of spermidine synthase as a drug target in African trypanosomes.
@en
type
label
Validation of spermidine synthase as a drug target in African trypanosomes.
@ast
Validation of spermidine synthase as a drug target in African trypanosomes.
@en
prefLabel
Validation of spermidine synthase as a drug target in African trypanosomes.
@ast
Validation of spermidine synthase as a drug target in African trypanosomes.
@en
P2093
P2860
P356
P1433
P1476
Validation of spermidine synthase as a drug target in African trypanosomes
@en
P2093
Bernard Blessington
Harparkash Kaur
John M Kelly
Shane R Wilkinson
P2860
P304
P356
10.1042/BJ20071185
P407
P577
2008-01-01T00:00:00Z