Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a rec
about
The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifsEvolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).Structural considerations of vitamin D signalingDesign, synthesis, evaluation, and structure of vitamin D analogues with furan side chainsCrystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivativesHydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimerFunctional evolution of the vitamin D and pregnane X receptors.Evolution of pharmacologic specificity in the pregnane X receptor.On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist.Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment.Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.A human vitamin D receptor mutant activated by cholecalciferol.New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model.Efficient stable isotope labeling and purification of vitamin D receptor from inclusion bodies.Steroids: partial synthesis in medicinal chemistry.Functional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist.Covalent labeling of nuclear vitamin D receptor with affinity labeling reagents containing a cross-linking probe at three different positions of the parent ligand: structural and biochemical implications.The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung.Vitamin D receptor ligands: the impact of crystal structures.Vitamin D receptor agonists' anti-inflammatory properties.The retinoid X receptor ligand restores defective signalling by the vitamin D receptor.Vitamin D receptor agonists specifically modulate the volume of the ligand-binding pocket.Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays.
P2860
Q24294517-9E445700-BA39-4C6E-BAF1-4BA5F60F1883Q24815571-F2D42050-4649-4BD9-B6C3-3CF3146913FBQ27022483-462123F2-5533-4AAB-9CF4-0E666F1B00F0Q27676147-782C55DD-7304-4B71-ADE2-4CFB5A9245ABQ27678429-2C91A6DE-863F-4FBE-B7B2-EFECB94E1F7CQ30497045-94760B76-D63E-469D-A0B0-6FD53FEF9592Q30838213-B5DE0EA5-5DE4-4592-B5D5-AE39D71222DCQ33326759-DC458966-5F04-4BE7-9032-B82EA33BCE0BQ33508413-4F298E2A-8EBD-4E06-8C10-CED1826E347DQ33881667-507E45BB-5828-4A20-8A7B-C584D401B3C8Q34621641-434C4ACD-2A50-4706-9E95-F2645A5D58F9Q35017142-0BD01428-66CA-41D0-B2D6-9DB4235A80FDQ35868761-76D253C3-4A31-42BC-BF6B-EFE422AB05DAQ36203324-899AA4C1-0647-4FF9-8C2B-DE083B2D620CQ36384495-DE6157F5-8849-401B-87CA-35DCCDB49228Q36440155-5E86E6EA-596D-42D4-854A-D706D01397A5Q36440873-1F9C5A80-59B3-410D-A77E-FF17C69AD8C1Q36718441-12F29C2D-1DCF-46B7-B5CD-CD89FA6DC330Q37226982-96D14FA4-4C30-4873-9F2C-0E7D8BF9DC60Q37355157-444B3756-D0C2-461C-B48C-58988D978452Q37997100-BB20ACA7-8384-487D-A882-DAF6063A07D1Q38206253-B01C2D13-2B74-4232-BDBB-832D883D5095Q38778401-C20EA71D-3CD5-43E0-8F61-9F0266E5C7B9Q40316418-020AA1B7-1D88-4BE0-9249-1BBEADB23FD9Q55384631-04D8428C-223D-49AF-A644-EF9BB1F3CBEB
P2860
Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a rec
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Crystal structures of the vita ...... ching of calcipotriol to a rec
@en
Crystal structures of the vita ...... ching of calcipotriol to a rec
@nl
type
label
Crystal structures of the vita ...... ching of calcipotriol to a rec
@en
Crystal structures of the vita ...... ching of calcipotriol to a rec
@nl
prefLabel
Crystal structures of the vita ...... ching of calcipotriol to a rec
@en
Crystal structures of the vita ...... ching of calcipotriol to a rec
@nl
P921
P356
P1476
Crystal structures of the vita ...... ching of calcipotriol to a rec
@en
P2093
Dino Moras
Giuseppe Tocchini-Valentini
P304
P356
10.1021/JM0310582
P407
P577
2004-04-01T00:00:00Z