Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility.
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Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indicationsImpact of soluble epoxide hydrolase and epoxyeicosanoids on human healthSoluble epoxide hydrolase inhibitors and heart failureSoluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophySoluble epoxide hydrolase: a novel therapeutic target in strokePharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammationSoluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertensionThe role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airwaysThe 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic painEpoxides and soluble epoxide hydrolase in cardiovascular physiologyPharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogsQuantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometryInhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory painSoluble epoxide hydrolase is a therapeutic target for acute inflammationDevelopment of a high-throughput screen for soluble epoxide hydrolase inhibitionFluorescent substrates for soluble epoxide hydrolase and application to inhibition studies.The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolaseSolid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors.Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors.Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury.Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties.Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats.Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase.Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesSynthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors.Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases.PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPSAn orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertensionAn epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive ratsCardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injuryCharacterization of an epoxide hydrolase from the Florida red tide dinoflagellate, Karenia brevisCytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodelingPharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors.Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase.Emerging role of epoxyeicosatrienoic acids in coronary vascular function.Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models.Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG¹²D/Pdx-1-Cre Mice.Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.
P2860
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P2860
Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Design, synthesis, and biologi ...... of increased water solubility.
@en
Design, synthesis, and biologi ...... of increased water solubility.
@nl
type
label
Design, synthesis, and biologi ...... of increased water solubility.
@en
Design, synthesis, and biologi ...... of increased water solubility.
@nl
prefLabel
Design, synthesis, and biologi ...... of increased water solubility.
@en
Design, synthesis, and biologi ...... of increased water solubility.
@nl
P2093
P356
P1476
Design, synthesis, and biologi ...... of increased water solubility.
@en
P2093
Bruce D Hammock
Christophe Morisseau
In-Hae Kim
Takaho Watanabe
P304
P356
10.1021/JM030514J
P407
P577
2004-04-01T00:00:00Z