Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. - Wikidata - awgldk - TriplyDB

Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa.

Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa.

http://www.wikidata.org/entity/Q44868831

about

Precision editing of large animal genomes Engineering large animal models of human disease Current progress of genetically engineered pig models for biomedical research Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy Rhodopsin mutant P23H destabilizes rod photoreceptor disk membranes Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability Cone degeneration following rod ablation in a reversible model of retinal degeneration.A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers A battery of cell- and structure-specific markers for the adult porcine retina.Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosa.Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice.Transgenic pigs with pancreas-specific expression of green fluorescent protein.Recent advances in the molecular basis of inherited photoreceptor degeneration.Molecular ophthalmology: an update on animal models for retinal degenerations and dystrophies RGS9 knockout causes a short delay in light responses of ON-bipolar cells.Gene augmentation for adRP mutations in RHO.Gene therapy and retinitis pigmentosa: advances and future challenges.Rod photoreceptor temporal properties in retinal degenerative diseases.Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography Isolation of progenitor cells from GFP-transgenic pigs and transplantation to the retina of allorecipients Pathways to photoreceptor cell death in inherited retinal degenerations.Finding and interpreting genetic variations that are important to ophthalmologists.Self-complementary AAV-mediated gene therapy restores cone function and prevents cone degeneration in two models of Rpe65 deficiency.Completion of the swine genome will simplify the production of swine as a large animal biomedical model.Human cytokines activate JAK-STAT signaling pathway in porcine ocular tissue Animal transgenesis: state of the art and applications.Immunohistochemical study of pig retinal development Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoforms α1, α2, α3 and the ATP1A3 promoter.AAV-mediated photoreceptor transduction of the pig cone-enriched retina.Selective rod degeneration and partial cone inactivation characterize an iodoacetic acid model of Swine retinal degeneration.A future for transgenic livestock.Effect of rapamycin on the fate of P23H opsin associated with retinitis pigmentosa (an American Ophthalmological Society thesis).Genetically engineered pig models for human diseases.Generation of an inbred miniature pig model of retinitis pigmentosa.Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study.Synchronization and superovulation of mature cycling gilts for the collection of pronuclear stage embryos.A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.Pigs taking wing with transposons and recombinases.

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P2860

Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa.

http://www.wikidata.org/entity/Q44868831

description

1997 nî lūn-bûn

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Genetically engineered large a ...... ation in retinitis pigmentosa.

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Genetically engineered large a ...... ation in retinitis pigmentosa.

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Genetically engineered large a ...... ation in retinitis pigmentosa.

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Genetically engineered large a ...... ation in retinitis pigmentosa.

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Nature Biotechnology

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Genetically engineered large a ...... ation in retinitis pigmentosa.

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Alexander CA

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Banin E

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P2860

Rapid and efficient site-specific mutagenesis without phenotypic selection

Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa

Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa.

Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice.

Transgenic mice carrying the dominant rhodopsin mutation P347S: evidence for defective vectorial transport of rhodopsin to the outer segments.

bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations.

Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina.

An alternative phototransduction model for human rod and cone ERG a-waves: normal parameters and variation with age.

Retinal Function and Rhodopsin Levels in Autosomal Dominant Retinitis Pigmentosa With Rhodopsin Mutations

Ocular Findings in Patients with Autosomal Dominant Retinitis Pigmentosa and Rhodopsin, Proline-347-Leucine

P2888

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965-970

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10.1038/NBT1097-965

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15

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