Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine.
about
Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1.Attacking the supply wagons to starve cancer cells to death.Fingolimod (FTY720) stimulates Ca(2+)/calcineurin signaling in fission yeast.Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteinsSphingolipids function as downstream effectors of a fungal PAQR.Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.Roles for sphingolipids in Saccharomyces cerevisiae.Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo.Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.Amino Acid Metabolism and Transport Mechanisms as Potential Antifungal Targets.
P2860
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P2860
Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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name
Genetic, biochemical, and tran ...... sphingolipid phytosphingosine.
@en
Genetic, biochemical, and tran ...... sphingolipid phytosphingosine.
@nl
type
label
Genetic, biochemical, and tran ...... sphingolipid phytosphingosine.
@en
Genetic, biochemical, and tran ...... sphingolipid phytosphingosine.
@nl
prefLabel
Genetic, biochemical, and tran ...... sphingolipid phytosphingosine.
@en
Genetic, biochemical, and tran ...... sphingolipid phytosphingosine.
@nl
P2093
P2860
P356
P1476
Genetic, biochemical, and tran ...... sphingolipid phytosphingosine.
@en
P2093
Carole A Welsch
Jean François Goetschy
Lukas W A Roth
N Rao Movva
P2860
P304
36720-36731
P356
10.1074/JBC.M406179200
P407
P577
2004-06-09T00:00:00Z