Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
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Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb ActivationA screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila.Sphingosine kinase 1 isoform-specific interactions in breast cancerTreatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.Extracellular and intracellular actions of sphingosine-1-phosphateSphingolipids in multiple sclerosis.Patterning of leaf vein networks by convergent auxin transport pathways.FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma.Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolinBACE1 activity is modulated by cell-associated sphingosine-1-phosphate.Targeting sphingosine-1-phosphate in hematologic malignancies(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activityPulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720.A fluorescent assay for ceramide synthase activity.The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer.Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.Sphingosine-1-phosphate Receptor Agonism Reduces Bordetella pertussis-mediated Lung PathologyLocal not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza.FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathwayA lipid binding domain in sphingosine kinase 2Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2.Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro.Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis.A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation.Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease.Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism.Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod).Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation.Fingolimod induces neuronal-specific gene expression with potential neuroprotective outcomes in maturing neuronal progenitor cells exposed to HIV.Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain.Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways.Selective inhibition of sphingosine kinase-1 protects adipose tissue against LPS-induced inflammatory response in Zucker diabetic fatty rats.Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction.Sphingosine-1-phosphate signaling in human submandibular cells.The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders.
P2860
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P2860
Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Essential requirement for sphi ...... activated by FTY720 analogues.
@en
Essential requirement for sphi ...... activated by FTY720 analogues.
@nl
type
label
Essential requirement for sphi ...... activated by FTY720 analogues.
@en
Essential requirement for sphi ...... activated by FTY720 analogues.
@nl
prefLabel
Essential requirement for sphi ...... activated by FTY720 analogues.
@en
Essential requirement for sphi ...... activated by FTY720 analogues.
@nl
P2093
P2860
P356
P1476
Essential requirement for sphi ...... activated by FTY720 analogues.
@en
P2093
Anthony S Don
Carolina Martinez-Lamenca
Ed Roberts
Hugh Rosen
Richard L Proia
William R Webb
P2860
P304
15833-15842
P356
10.1074/JBC.M609124200
P407
P577
2007-03-30T00:00:00Z