Double-strand DNA break formation mediated by flap endonuclease-1.
about
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason scoreAlkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.Repair of single-strand DNA interruptions by redundant pathways and its implication in cellular sensitivity to DNA-damaging agentsThe transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.Induction of base damages representing a high risk site for double-strand DNA break formation in genomic DNA by exposure of cells to DNA damaging agents.Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.
P2860
Double-strand DNA break formation mediated by flap endonuclease-1.
description
2003 nî lūn-bûn
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name
Double-strand DNA break formation mediated by flap endonuclease-1.
@en
Double-strand DNA break formation mediated by flap endonuclease-1.
@nl
type
label
Double-strand DNA break formation mediated by flap endonuclease-1.
@en
Double-strand DNA break formation mediated by flap endonuclease-1.
@nl
prefLabel
Double-strand DNA break formation mediated by flap endonuclease-1.
@en
Double-strand DNA break formation mediated by flap endonuclease-1.
@nl
P2093
P2860
P356
P1476
Double-strand DNA break formation mediated by flap endonuclease-1.
@en
P2093
Erick L Y Ho
Masahiko S Satoh
Stephane Vispé
Tetsu M C Yung
P2860
P304
35279-35285
P356
10.1074/JBC.M303448200
P407
P577
2003-06-27T00:00:00Z