Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel.
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New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channelsMolecular targets for antiepileptic drug developmentIon channels as drug targets in central nervous system disordersRetigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 MutationsProtein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activityRetigabine/Ezogabine, a KCNQ/K(V)7 channel opener: pharmacological and clinical data.Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration.Contributions of Kv7-mediated potassium current to sub- and suprathreshold responses of rat layer II/III neocortical pyramidal neurons.Clinical utility of adjunctive retigabine in partial onset seizures in adults.Challenges and opportunities in the application of pharmacogenetics to antiepileptic drug therapy.Strain and age affect electroconvulsive seizure testing in rats.Traumatic brain injury during development reduces minimal clonic seizure thresholds at maturity.A locus on mouse Ch10 influences susceptibility to limbic seizure severity: fine mapping and in silico candidate gene analysis.The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use.Potassium Channels in Epilepsy.Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption.Efficacy of Retigabine on Acute Limbic Seizures in Adult Rats.Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.Linkage study of voltage-gated potassium channels in familial mesial temporal lobe epilepsy.A companion to the preclinical common data elements for pharmacologic studies in animal models of seizures and epilepsy. A Report of the TASK3 Pharmacology Working Group of the ILAE/AES Joint Translational Task Force
P2860
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P2860
Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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name
Mice carrying the szt1 mutatio ...... ounds acting at the m-channel.
@en
Mice carrying the szt1 mutatio ...... ounds acting at the m-channel.
@nl
type
label
Mice carrying the szt1 mutatio ...... ounds acting at the m-channel.
@en
Mice carrying the szt1 mutatio ...... ounds acting at the m-channel.
@nl
prefLabel
Mice carrying the szt1 mutatio ...... ounds acting at the m-channel.
@en
Mice carrying the szt1 mutatio ...... ounds acting at the m-channel.
@nl
P2093
P2860
P1433
P1476
Mice carrying the szt1 mutatio ...... ounds acting at the m-channel.
@en
P2093
H Steve White
James F Otto
Karen S Wilcox
Wayne N Frankel
P2860
P304
P356
10.1111/J.0013-9580.2004.65703.X
P577
2004-09-01T00:00:00Z