Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

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http://www.wikidata.org/entity/Q45040921
Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability.Prediction of hepatic clearance in human from in vitro data for successful drug development.Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.Applications of human pharmacokinetic prediction in first-in-human dose estimationGomisin A is a Novel Isoform-Specific Probe for the Selective Sensing of Human Cytochrome P450 3A4 in Liver Microsomes and Living Cells.In vitro screening of drug metabolism during drug development: can we trust the predictions?Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation.Drugs as CYP3A probes, inducers, and inhibitors.Modeling and predicting drug pharmacokinetics in patients with renal impairment.Influence of ethnicity on response to asthma drugs.Reaction phenotyping to assess victim drug-drug interaction risks.The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam.Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized.Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model.
P2860

Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

Item
http://www.wikidata.org/entity/Q45040921
description
2004 nî lūn-bûn
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2004年の論文
@ja
2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
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2004年學術文章
@zh-hant
name
Utility of recombinant enzyme ...... 19 on CYP3A4 probe substrates.
@en
Utility of recombinant enzyme ...... 19 on CYP3A4 probe substrates.
@nl
type
label
Utility of recombinant enzyme ...... 19 on CYP3A4 probe substrates.
@en
Utility of recombinant enzyme ...... 19 on CYP3A4 probe substrates.
@nl
prefLabel
Utility of recombinant enzyme ...... 19 on CYP3A4 probe substrates.
@en
Utility of recombinant enzyme ...... 19 on CYP3A4 probe substrates.
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
Utility of recombinant enzyme ...... C19 on CYP3A4 probe substrates
@en
P2093
P304
P31
P356
P433
P478
P50
P577
P698