Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.
about
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.Assessment of in silico models for fraction of unbound drug in human liver microsomes.Prediction of human pharmacokinetics--gut-wall metabolism.Applications of human pharmacokinetic prediction in first-in-human dose estimationPrediction of human pharmacokinetics--evaluation of methods for prediction of volume of distribution.Prediction of human pharmacokinetics - renal metabolic and excretion clearance.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Prediction of human pharmacokinetics-biliary and intestinal clearance and enterohepatic circulation.Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects.From known knowns to known unknowns: predicting in vivo drug metabolites.Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results.Prediction of morphine clearance in the paediatric population : how accurate are the available pharmacokinetic models?Prediction of drug disposition on the basis of its chemical structure.Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.Prediction of human pharmacokinetics--improving microsome-based predictions of hepatic metabolic clearance.Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction.The use of isolated enterocytes to study Phase I intestinal drug metabolism: validation with rat and pig intestine.Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds.Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms.
P2860
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P2860
Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Prediction of human pharmacoki ...... f hepatic metabolic clearance.
@en
Prediction of human pharmacoki ...... f hepatic metabolic clearance.
@nl
type
label
Prediction of human pharmacoki ...... f hepatic metabolic clearance.
@en
Prediction of human pharmacoki ...... f hepatic metabolic clearance.
@nl
prefLabel
Prediction of human pharmacoki ...... f hepatic metabolic clearance.
@en
Prediction of human pharmacoki ...... f hepatic metabolic clearance.
@nl
P2860
P356
P1476
Prediction of human pharmacoki ...... f hepatic metabolic clearance.
@en
P2093
Urban Fagerholm
P2860
P304
P356
10.1211/JPP.59.6.0007
P577
2007-06-01T00:00:00Z