Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model.
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Rapid determination of hydrogen positions and protonation states of diisopropyl fluorophosphatase by joint neutron and X-ray diffraction refinementVX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results.Mechanistic Insights into the Hydrolysis of Organophosphorus Compounds by Paraoxonase-1: Exploring the Limits of Substrate Tolerance in a Promiscuous Enzyme.Toward Understanding the Catalytic Mechanism of Human Paraoxonase 1: Site-Specific Mutagenesis at Position 192Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.Crystal structure and characterization of esterase Est25 mutants reveal improved enantioselectivity toward (S)-ketoprofen ethyl ester.Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights.IgG-paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier.Catalytic mechanisms for phosphotriesterasesHomology modeling of human serum paraoxonase1 and its molecular interaction studies with aspirin and cefazolin.Current and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes.Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes.Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase.Comparative modeling of PON2 and analysis of its substrate binding interactions using computational methods.CHO cell expression, long-term stability, and primate pharmacokinetics and brain uptake of an IgG-paroxonase-1 fusion protein.In silico analyses of substrate interactions with human serum paraoxonase 1.Analysis of active-site amino-acid residues of human serum paraoxonase using competitive substrates.Serum PON1 arylesterase activity in relation to hyperhomocysteinaemia and oxidative stress in young adult central retinal venous occlusion patients.The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases.Towards Understanding the Catalytic Mechanism of Human Paraoxonase 1: Experimental and In Silico Mutagenesis Studies.Rational design of paraoxonase 1 (PON1) for the efficient hydrolysis of organophosphates.Paraoxonase 1 activity in patients with chronic obstructive pulmonary disease.Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase
P2860
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P2860
Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model.
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2004 nî lūn-bûn
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name
Structure/function analyses of ...... a DFPase-like homology model.
@en
Structure/function analyses of human serum paraoxonase
@nl
type
label
Structure/function analyses of ...... a DFPase-like homology model.
@en
Structure/function analyses of human serum paraoxonase
@nl
prefLabel
Structure/function analyses of ...... a DFPase-like homology model.
@en
Structure/function analyses of human serum paraoxonase
@nl
P2093
P1476
Structure/function analyses of ...... a DFPase-like homology model.
@en
P2093
Akhil Khanal
Brian J Bahnson
Christopher W McAndrew
David E Lenz
David T Yeung
Denis Josse
Douglas M Cerasoli
James D Nicholson
P356
10.1016/J.BBAPAP.2004.08.002
P577
2004-10-01T00:00:00Z