The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases.
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Structural and mutational analyses of Drp35 from Staphylococcus aureus: a possible mechanism for its lactonase activitySwitching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263TrpValidation of PON1 enzyme activity assays for longitudinal studiesHuman paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological rolesOne enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activityStereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.Hydrolysis of DFP and the nerve agent (S)-sarin by DFPase proceeds along two different reaction pathways: implications for engineering bioscavengers.VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results.Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.Mechanistic Insights into the Hydrolysis of Organophosphorus Compounds by Paraoxonase-1: Exploring the Limits of Substrate Tolerance in a Promiscuous Enzyme.Serum paraoxonase 1 (PON1) measurement: an update.In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases.Toward Understanding the Catalytic Mechanism of Human Paraoxonase 1: Site-Specific Mutagenesis at Position 192Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.Molecular Dynamics Approach in the Comparison of Wild-Type and Mutant Paraoxonase-1 Apoenzyme Form.Tracing determinants of dual substrate specificity in glycoside hydrolase family 5.Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context-Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space.Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein InteractionThe evolution of function in strictosidine synthase-like proteins.Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights.Characterization of human paraoxonase 1 variants suggest that His residues at 115 and 134 positions are not always needed for the lactonase/arylesterase activities of the enzyme.Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women.Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1.Divergence and convergence in enzyme evolution: parallel evolution of paraoxonases from quorum-quenching lactonasesCatalytic mechanisms for phosphotriesterasesHomology modeling of human serum paraoxonase1 and its molecular interaction studies with aspirin and cefazolin.Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates.Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes.Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase.The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux.PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways.Tracing the Repertoire of Promiscuous Enzymes along the Metabolic Pathways in Archaeal Organisms.Measurement of serum paraoxonase-1 activity in the evaluation of liver function.Latent evolutionary potentials under the neutral mutational drift of an enzyme.Molecular dynamics simulation of human serum paraoxonase 1 in DPPC bilayer reveals a critical role of transmembrane helix H1 for HDL association.Novel serum paraoxonase activity assays are associated with coronary artery disease.Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.Ocular distribution of antioxidant enzyme paraoxonase & its alteration in cataractous lens & diabetic retina.Similar Active Sites and Mechanisms Do Not Lead to Cross-Promiscuity in Organophosphate Hydrolysis: Implications for Biotherapeutic Engineering.Towards Understanding the Catalytic Mechanism of Human Paraoxonase 1: Experimental and In Silico Mutagenesis Studies.
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P2860
The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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name
The histidine 115-histidine 13 ...... mammalian serum paraoxonases.
@en
The histidine 115-histidine 13 ...... mammalian serum paraoxonases.
@nl
type
label
The histidine 115-histidine 13 ...... mammalian serum paraoxonases.
@en
The histidine 115-histidine 13 ...... mammalian serum paraoxonases.
@nl
prefLabel
The histidine 115-histidine 13 ...... mammalian serum paraoxonases.
@en
The histidine 115-histidine 13 ...... mammalian serum paraoxonases.
@nl
P2860
P356
P1476
The histidine 115-histidine 13 ...... mammalian serum paraoxonases.
@en
P2093
Dan S Tawfik
Olga Khersonsky
P2860
P304
P356
10.1074/JBC.M512594200
P407
P577
2006-01-10T00:00:00Z