TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.
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Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsThe cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory DiseasesMolecular mechanisms underlying β-adrenergic receptor-mediated cross-talk between sympathetic neurons and immune cellsMiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway.PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling.Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice.Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4DThe acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulinPhosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthmaCyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression.PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblastsCaveolae as organizers of pharmacologically relevant signal transduction molecules.Lipid raft redox signaling: molecular mechanisms in health and disease.Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsModulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex.Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle.Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.Creating order from chaos: cellular regulation by kinase anchoring.Inhibition of Gαs/cAMP Signaling Decreases TCR-Stimulated IL-2 transcription in CD4(+) T Helper Cells.Signaling defects in anti-tumor T cellsCompartmentalization of cyclic nucleotide signaling: a question of when, where, and why?Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors.Molecular mechanisms that control mouse and human TCR-alphabeta and TCR-gammadelta T cell development.Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.Clinical and molecular genetics of the phosphodiesterases (PDEs).Decreased Gαq expression in T cells correlates with enhanced cytokine production and disease activity in systemic lupus erythematosus.Regulation of T cells in airway disease by beta-agonist.Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states.Regulation of lymphocyte function by adenosine.Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases.β-Arrestins in the immune systemAnalyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells.Phosphodiesterase-4 inhibition as a therapeutic strategy for metabolic disorders.The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation.
P2860
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P2860
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
TCR- and CD28-mediated recruit ...... fts potentiates TCR signaling.
@en
TCR- and CD28-mediated recruit ...... fts potentiates TCR signaling.
@nl
type
label
TCR- and CD28-mediated recruit ...... fts potentiates TCR signaling.
@en
TCR- and CD28-mediated recruit ...... fts potentiates TCR signaling.
@nl
prefLabel
TCR- and CD28-mediated recruit ...... fts potentiates TCR signaling.
@en
TCR- and CD28-mediated recruit ...... fts potentiates TCR signaling.
@nl
P2093
P50
P1476
TCR- and CD28-mediated recruit ...... fts potentiates TCR signaling.
@en
P2093
Anja Ruppelt
George Baillie
Hilde Abrahamsen
Jacob Ngai
Konstantina Nika
Tomas Mustelin
Torkel Vang
P304
P356
10.4049/JIMMUNOL.173.8.4847
P407
P577
2004-10-01T00:00:00Z