Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane.
about
Ezetimibe therapy: mechanism of action and clinical updateThe target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)Mass spectrometry-based proteomics and its application to studies of Porphyromonas gingivalis invasion and pathogenicity.CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouseNPC1L1 and cholesterol transportA stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestineThe role of multifunctional M1 metallopeptidases in cell cycle progressionProtein mediators of sterol transport across intestinal brush border membrane.CD13/APN regulates endothelial invasion and filopodia formationIdentification of alanyl aminopeptidase (CD13) as a surface marker for isolation of mature gastric zymogenic chief cells.Emerging roles of the intestine in control of cholesterol metabolism.Non-low-density lipoprotein cholesterol-associated actions of ezetimibe: an overview.Analysis of the immune response of human dendritic cells to Mycobacterium tuberculosis by quantitative proteomics.The role of Niemann-Pick C1 - Like 1 (NPC1L1) in intestinal sterol absorptionNiemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport.The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36.Receptor for the F4 fimbriae of enterotoxigenic Escherichia coli (ETEC).Sequence-specific alterations of epitope production by HIV protease inhibitors.Ezetimibe reduces plaque inflammation in a rabbit model of atherosclerosis and inhibits monocyte migration in addition to its lipid-lowering effect.Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake.CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptakeScavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyteAminopeptidase N (CD13) is involved in phagocytic processes in human dendritic cells and macrophagesThe catalytic and protein-protein interaction domains are required for APM1 function.Pleiotropic effects of atorvastatin on monocytes in atherosclerotic patients.Mutation of the membrane-associated M1 protease APM1 results in distinct embryonic and seedling developmental defects in Arabidopsis.Aminopeptidase N facilitates entry and intracellular survival of Mycobacterium tuberculosis in monocytes.Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8.Role of the apical and basolateral domains of the enterocyte in the regulation of cholesterol transport by a high glucose concentration.Comparison of different vehicles to study the effect of tocopherols on gene expression in intestinal cells.Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels.Chronic restraint stress induces intestinal inflammation and alters the expression of hexose and lipid transporters.Distinct Epitopes on CD13 Mediate Opposite Consequences for Cell Adhesion.
P2860
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P2860
Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane.
description
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Aminopeptidase N (CD13) is a m ...... erocyte brush border membrane.
@en
type
label
Aminopeptidase N (CD13) is a m ...... erocyte brush border membrane.
@en
prefLabel
Aminopeptidase N (CD13) is a m ...... erocyte brush border membrane.
@en
P2093
P2860
P356
P1476
Aminopeptidase N (CD13) is a m ...... erocyte brush border membrane.
@en
P2093
Anja Pfenninger
Daniel Corsiero
Elisabeth O Hochleitner
Evelyn Orsó
Frank Girbig
Friedrich Lottspeich
Gerd Schmitz
Gerhard Jähne
Matthias Rhein
Wendelin Frick
P2860
P304
P356
10.1074/JBC.M406309200
P407
P577
2004-10-19T00:00:00Z