Determination of the functional unit of the cystic fibrosis transmembrane conductance regulator chloride channel. One polypeptide forms one pore.
about
The ABC protein turned chloride channel whose failure causes cystic fibrosisThree charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.The block of CFTR by scorpion venom is state-dependentCFTR: Ligand exchange between a permeant anion ([Au(CN)2]-) and an engineered cysteine (T338C) blocks the pore.Modeling the conformational changes underlying channel opening in CFTRRecent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.Mutations at arginine 352 alter the pore architecture of CFTR.Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domainTwo salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.State-dependent chemical reactivity of an engineered cysteine reveals conformational changes in the outer vestibule of the cystic fibrosis transmembrane conductance regulator.A high-field solid-state 35/37Cl NMR and quantum chemical investigation of the chlorine quadrupolar and chemical shift tensors in amino acid hydrochlorides.A possible role for intracellular GSH in spontaneous reaction of a cysteine (T338C) engineered into the Cystic Fibrosis Transmembrane Conductance Regulator.ATP hydrolysis-dependent asymmetry of the conformation of CFTR channel pore.
P2860
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P2860
Determination of the functional unit of the cystic fibrosis transmembrane conductance regulator chloride channel. One polypeptide forms one pore.
description
2004 nî lūn-bûn
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name
Determination of the functiona ...... ne polypeptide forms one pore.
@en
Determination of the functiona ...... ne polypeptide forms one pore.
@nl
type
label
Determination of the functiona ...... ne polypeptide forms one pore.
@en
Determination of the functiona ...... ne polypeptide forms one pore.
@nl
prefLabel
Determination of the functiona ...... ne polypeptide forms one pore.
@en
Determination of the functiona ...... ne polypeptide forms one pore.
@nl
P2093
P2860
P356
P1476
Determination of the functiona ...... ne polypeptide forms one pore.
@en
P2093
Binlin Song
David C Dawson
Guiying Cui
Nael A McCarty
Xuehong Liu
Zhi-Ren Zhang
P2860
P304
P356
10.1074/JBC.M409626200
P407
P577
2004-10-25T00:00:00Z