Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i.

Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i.

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http://www.wikidata.org/entity/Q45146814
PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamicsPharmGKB summary: very important pharmacogene information for RYR1RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes.A malignant hyperthermia-inducing mutation in RYR1 (R163C): alterations in Ca2+ entry, release, and retrograde signaling to the DHPR.Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice.Malignant hyperthermia: a pharmacogenetic disorder.Gain of function in the immune system caused by a ryanodine receptor 1 mutation.A recessive ryanodine receptor 1 mutation in a CCD patient increases channel activity.Membrane depolarization increases ryanodine sensitivity to Ca2+ release to the cytosol in L6 skeletal muscle cells: Implications for excitation-contraction couplingRyanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95).Estrogens Protect Calsequestrin-1 Knockout Mice from Lethal Hyperthermic Episodes by Reducing Oxidative Stress in Muscle.Dysregulation of Intracellular Ca2+ in Dystrophic Cortical and Hippocampal Neurons.
P2860

Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i.

Item
http://www.wikidata.org/entity/Q45146814
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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Enhanced response to caffeine ...... ally elevated resting [Ca2+]i.
@en
Enhanced response to caffeine ...... ally elevated resting [Ca2+]i.
@nl
type
label
Enhanced response to caffeine ...... ally elevated resting [Ca2+]i.
@en
Enhanced response to caffeine ...... ally elevated resting [Ca2+]i.
@nl
prefLabel
Enhanced response to caffeine ...... ally elevated resting [Ca2+]i.
@en
Enhanced response to caffeine ...... ally elevated resting [Ca2+]i.
@nl
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Enhanced response to caffeine ...... ally elevated resting [Ca2+]i.
@en
P2093
P2860
P304
P31
P356
10.1152/AJPCELL.00297.2004
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