The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion.
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The Mediator subunit MDT-15 confers metabolic adaptation to ingested materialRole of pregnane X receptor in chemotherapeutic treatmentPXR variants: the impact on drug metabolism and therapeutic responsesAssociation of ABCB1 genetic variants with renal function in Africans and in Caucasians.Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination.The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptorActivation of xenobiotic receptors: driving into the nucleus.p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis.Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptorTaxane pathway.Tissue-specific regulation of pregnane X receptor in cancer development and therapy.Adaptive and specialised transcriptional responses to xenobiotic stress in Caenorhabditis elegans are regulated by nuclear hormone receptors.Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells.Novel substrates for, and sources of, progestogens for reproduction.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.CAR and PXR: the xenobiotic-sensing receptors.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.Role of CAR and PXR in xenobiotic sensing and metabolism.Expression of the PXR gene in various types of cancer and drug resistanceNovel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXRInduction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations.Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention.Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats.Antiproliferative efficacies but minor drug transporter inducing effects of paclitaxel, cisplatin, or 5-fluorouracil in a murine xenograft model for head and neck squamous cell carcinoma.Expression of steroid and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma.Are pharmacogenomic biomarkers an effective tool to predict taxane toxicity and outcome in breast cancer patients? Literature review.The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2).Affinity purification using recombinant PXR as a tool to characterize environmental ligands.The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes.Rexinoids modulate steroid and xenobiotic receptor activity by increasing its protein turnover in a calpain-dependent manner.Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.CYP450 polymorphisms predict clinic outcomes to vinorelbine-based chemotherapy in patients with non-small-cell lung cancer.Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma.
P2860
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P2860
The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
@zh-hans
2005年学术文章
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2005年学术文章
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2005年學術文章
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2005年學術文章
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name
The pregnane X receptor regula ...... nd promoter-selective fashion.
@en
The pregnane X receptor regula ...... nd promoter-selective fashion.
@nl
type
label
The pregnane X receptor regula ...... nd promoter-selective fashion.
@en
The pregnane X receptor regula ...... nd promoter-selective fashion.
@nl
prefLabel
The pregnane X receptor regula ...... nd promoter-selective fashion.
@en
The pregnane X receptor regula ...... nd promoter-selective fashion.
@nl
P2093
P356
P1476
The pregnane X receptor regula ...... nd promoter-selective fashion.
@en
P2093
Hideki Nakatsukasa
Hisashi Masuyama
Naoko Suwaki
Tomonori Segawa
Yoko Tateishi
Yuji Hiramatsu
P304
P356
10.1210/ME.2004-0434
P577
2005-01-13T00:00:00Z