Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation.
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In silico discovery of aminoacyl-tRNA synthetase inhibitorsStructural insights into the first step of RNA-dependent cysteine biosynthesis in archaeaSolution structure of HI1506, a novel two-domain protein fromHaemophilus influenzaeAn antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing siteModeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP)Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetaseUnveiling the structural basis for translational ambiguity tolerance in a human fungal pathogenDiscovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetaseStructural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetaseAssociation between Archaeal prolyl- and leucyl-tRNA synthetases enhances tRNA(Pro) aminoacylationLeucyl-tRNA synthetase from the ancestral bacterium Aquifex aeolicus contains relics of synthetase evolution.A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase.A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activityDetailed analysis of function divergence in a large and diverse domain superfamily: toward a refined protocol of function classificationDynamical networks in tRNA:protein complexes.Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module.A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.Degenerate connective polypeptide 1 (CP1) domain from human mitochondrial leucyl-tRNA synthetase.A Flexible peptide tether controls accessibility of a unique C-terminal RNA-binding domain in leucyl-tRNA synthetases.C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeuCrystallization and preliminary X-ray crystallographic study of alanyl-tRNA synthetase from the archaeon Archaeoglobus fulgidusCrucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing.Leucine-specific domain modulates the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetaseA unique insert of leucyl-tRNA synthetase is required for aminoacylation and not amino acid editing.Aminoacylation and translational quality control strategy employed by leucyl-tRNA synthetase from a human pathogen with genetic code ambiguitytRNAs: cellular barcodes for amino acids.Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode.Transfer RNA: a dancer between charging and mis-charging for protein biosynthesis.Crystallization and preliminary X-ray crystallographic study of the wild type and two mutants of the CP1 hydrolytic domain from Aquifex aeolicus leucyl-tRNA synthetase.The CP2 domain of leucyl-tRNA synthetase is crucial for amino acid activation and post-transfer editing.Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690.Functional characterization of leucine-specific domain 1 from eukaryal and archaeal leucyl-tRNA synthetases.Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination.Structural basis for non-cognate amino acid discrimination by the valyl-tRNA synthetase editing domain.The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation.Asymmetric behavior of archaeal prolyl-tRNA synthetase.Functional divergence of a unique C-terminal domain of leucyl-tRNA synthetase to accommodate its splicing and aminoacylation roles.Aminoacylation complex structures of leucyl-tRNA synthetase and tRNALeu reveal two modes of discriminator-base recognition
P2860
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P2860
Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Crystal structure of leucyl-tR ...... el editing domain orientation.
@en
Crystal structure of leucyl-tR ...... el editing domain orientation.
@nl
type
label
Crystal structure of leucyl-tR ...... el editing domain orientation.
@en
Crystal structure of leucyl-tR ...... el editing domain orientation.
@nl
prefLabel
Crystal structure of leucyl-tR ...... el editing domain orientation.
@en
Crystal structure of leucyl-tR ...... el editing domain orientation.
@nl
P1476
Crystal structure of leucyl-tR ...... el editing domain orientation.
@en
P356
10.1016/J.JMB.2004.11.060
P407
P577
2004-12-19T00:00:00Z