The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions.
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Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studiesRevisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viabilityPharmacophore modeling for anti-Chagas drug design using the fragment molecular orbital method.The Open Form Inducer Approach for Structure-Based Drug Design.Evolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion.Evaluation of high efficiency gene knockout strategies for Trypanosoma cruziKnockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.SUMOylation of paraflagellar rod protein, PFR1, and its stage-specific localization in Trypanosoma cruzi.Genome evolution in trypanosomatid parasites.Genetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani.Drug search for leishmaniasis: a virtual screening approach by grid computing.Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondiiGene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease.Comparative Metabolism of Free-living Bodo saltans and Parasitic Trypanosomatids.Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.Fumarate is an essential intermediary metabolite produced by the procyclic Trypanosoma brucei.Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotateCrystallization and preliminary X-ray diffraction analysis of Leishmania major dihydroorotate dehydrogenase.Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo.Genetically attenuated Trypanosoma cruzi parasites as a potential vaccination tool.Computational study of the mechanism of half-reactions in class 1A dihydroorotate dehydrogenase from Trypanosoma cruzi.Inositol 1,4,5-trisphosphate receptor regulates replication, differentiation, infectivity and virulence of the parasitic protist Trypanosoma cruzi.Identification of candidate pathogenicity determinants of Rhizoctonia solani AG1-IA, which causes sheath blight disease in rice.Fresh insights into the pyrimidine metabolism in the trypanosomatids.Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase from Trypanosoma brucei.Kinetoplastea
P2860
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P2860
The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
The origin of dihydroorotate d ...... aerobic, parasitic conditions.
@en
The origin of dihydroorotate d ...... aerobic, parasitic conditions.
@nl
type
label
The origin of dihydroorotate d ...... aerobic, parasitic conditions.
@en
The origin of dihydroorotate d ...... aerobic, parasitic conditions.
@nl
prefLabel
The origin of dihydroorotate d ...... aerobic, parasitic conditions.
@en
The origin of dihydroorotate d ...... aerobic, parasitic conditions.
@nl
P2093
P1476
The origin of dihydroorotate d ...... aerobic, parasitic conditions.
@en
P2093
Takashi Aoki
Takashi Makiuchi
Takeshi Annoura
Takeshi Nara
Tetsuo Hashimoto
P2888
P304
P356
10.1007/S00239-004-0078-8
P577
2005-01-01T00:00:00Z
P6179
1026054534