A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition.
about
Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metaboliteDNA adductomicsAnalytical tools and approaches for metabolite identification in early drug discovery.Data acquisition and data mining techniques for metabolite identification using LC coupled to high-resolution MS.Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MS(E) data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates.High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites.A statistical procedure to selectively detect metabolite signals in LC-MS data based on using variable isotope ratios.High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening.Application of LC-high-resolution MS with 'intelligent' data mining tools for screening reactive drug metabolites.Facilitated uptake of a bioactive metabolite of maritime pine bark extract (pycnogenol) into human erythrocytesA novel high-capacity ion trap-quadrupole tandem mass spectrometerDrug metabolite profiling and identification by high-resolution mass spectrometry.Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS.The generation, detection, and effects of reactive drug metabolites.Metabolite structure analysis by high-resolution MS: supporting drug-development studies.Hydrophilic interaction liquid chromatography coupled with MS/MS to detect and quantify dicarboxyethyl glutathione, a metabolic biomarker of the fumarate hydratase deficient cancer cell.Evaluation of the metabolism, bioactivation and pharmacokinetics of triaminopyrimidine analogs toward selection of a potential candidate for antimalarial therapy.Metabonomics biomarkers for subacute toxicity screening for benzene exposure in mice.Nucleophile addition of reduced glutathione on 2-methyl-2-nitroso compound: a combined electron paramagnetic resonance spectroscopy and electrospray tandem mass spectrometry study.Study of fragmentation behavior of amadori rearrangement products in lysine-containing peptide model by tandem mass spectrometry.Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation.Rapid and sensitive analysis of 27 underivatized free amino acids, dipeptides, and tripeptides in fruits of Siraitia grosvenorii Swingle using HILIC-UHPLC-QTRAP(®)/MS (2) combined with chemometrics methods.
P2860
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P2860
A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
A high-throughput liquid chrom ...... mass neutral loss acquisition.
@en
A high-throughput liquid chrom ...... mass neutral loss acquisition.
@nl
type
label
A high-throughput liquid chrom ...... mass neutral loss acquisition.
@en
A high-throughput liquid chrom ...... mass neutral loss acquisition.
@nl
prefLabel
A high-throughput liquid chrom ...... mass neutral loss acquisition.
@en
A high-throughput liquid chrom ...... mass neutral loss acquisition.
@nl
P2093
P356
P1476
A high-throughput liquid chrom ...... mass neutral loss acquisition.
@en
P2093
Jose Castro-Perez
Robert Plumb
P304
P356
10.1002/RCM.1855
P577
2005-01-01T00:00:00Z