Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.
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Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drugStructural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug actionReconstructing the Qo site of Plasmodium falciparum bc 1 complex in the yeast enzymeUnderstanding the mechanism of atovaquone drug resistance in Plasmodium falciparum cytochrome b mutation Y268S using computational methodsSequence Polymorphism of Cytochrome b Gene in Theileria annulata Tunisian Isolates and Its Association with Buparvaquone Treatment FailureParameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex.Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b geneEmergence of resistance to atovaquone-proguanil in malaria parasites: insights from computational modeling and clinical case reportsDifferent mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia.Novel Mutation in Cytochrome B of Plasmodium falciparum in One of Two Atovaquone-Proguanil Treatment Failures in Travelers Returning From Same Site in NigeriaSaccharomyces cerevisiae-based mutational analysis of the bc1 complex Qo site residue 279 to study the trade-off between atovaquone resistance and function.Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expressionHDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.Early treatment failure during treatment of Plasmodium falciparum malaria with atovaquone-proguanil in the Republic of Ivory CoastThe antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.Introduction of cytochrome b mutations in Saccharomyces cerevisiae by a method that allows selection for both functional and non-functional cytochrome b proteins.Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling.Antimalarial drugs: modes of action and mechanisms of parasite resistance.Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa.Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance.Sequence analysis of Plasmodium falciparum cytochrome b in multiple geographic sites.Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinonesIn vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand.Combining Inhibitor Resistance-conferring Mutations in Cytochrome b Creates Conditional Synthetic Lethality in Saccharomyces cerevisiae.A next-generation sequencing and bioinformatics protocol for Malaria drug Resistance marker Surveillance (MaRS).Phenotypic and genotypic characterization of Thai isolates of Plasmodium falciparum after an artemisinin resistance containment project.
P2860
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P2860
Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Cytochrome b mutations that mo ...... e in Saccharomyces cerevisiae.
@en
Cytochrome b mutations that mo ...... e in Saccharomyces cerevisiae.
@nl
type
label
Cytochrome b mutations that mo ...... e in Saccharomyces cerevisiae.
@en
Cytochrome b mutations that mo ...... e in Saccharomyces cerevisiae.
@nl
prefLabel
Cytochrome b mutations that mo ...... e in Saccharomyces cerevisiae.
@en
Cytochrome b mutations that mo ...... e in Saccharomyces cerevisiae.
@nl
P2093
P2860
P921
P356
P1476
Cytochrome b mutations that mo ...... e in Saccharomyces cerevisiae.
@en
P2093
Anne K Merritt
Benjamin B Lange
Bernard L Trumpower
Brigitte Meunier
Jacques J Kessl
Kevin H Ha
Philip Hill
P2860
P304
17142-17148
P356
10.1074/JBC.M500388200
P407
P577
2005-02-17T00:00:00Z