BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. - Wikidata - awgldk - TriplyDB

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

http://www.wikidata.org/entity/Q45275672

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Disturbed copper bioavailability in Alzheimer's disease Copper metallochaperones Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.Copper regulates cyclic-AMP-dependent lipolysis "Pulling the plug" on cellular copper: the role of mitochondria in copper export.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD Copper binding to the Alzheimer's disease amyloid precursor protein Beta-secretase: structure, function, and evolution.The risks of copper toxicity contributing to cognitive decline in the aging population and to Alzheimer's disease.Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease The Alzheimer's disease beta-secretase enzyme, BACE1.Amyloid precursor protein and BACE function as oligomers.Links between copper and cholesterol in Alzheimer's disease.The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.Therapeutics for Alzheimer's disease based on the metal hypothesis Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-κB pathway in a transgenic mouse model of Alzheimer's disease.X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease.The role of metallobiology and amyloid-β peptides in Alzheimer's disease.Biological metals and metal-targeting compounds in major neurodegenerative diseases.RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro.The secret life of extracellular vesicles in metal homeostasis and neurodegeneration.Potentiating role of copper on spatial memory deficit induced by beta amyloid and evaluation of mitochondrial function markers in the hippocampus of rats.The Mechanisms of Action of Curcumin in Alzheimer's Disease.Orchestration of dynamic copper navigation - new and missing pieces.Down-regulation of endogenous amyloid precursor protein processing due to cellular aging.Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate.Spectroscopic characterization of copper(I) binding to apo and metal-reconstituted zinc finger peptides.The influence of protein folding on the copper affinities of trafficking and target sites.GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer's disease.Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease.GULP1 is a novel APP-interacting protein that alters APP processing.O-linked glycosylation at threonine 27 protects the copper transporter hCTR1 from proteolytic cleavage in mammalian cells.Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.Role of amyloid-β–metal interactions in Alzheimer’s disease

P2860

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P2860

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

http://www.wikidata.org/entity/Q45275672

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

@zh-hans

2005年学术文章

@zh-my

2005年学术文章

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2005年學術文章

@yue

2005年學術文章

@zh

2005年學術文章

@zh-hant

name

BACE1 cytoplasmic domain inter ...... dismutase-1 and binds copper.

@en

BACE1 cytoplasmic domain inter ...... dismutase-1 and binds copper.

@nl

type

label

BACE1 cytoplasmic domain inter ...... dismutase-1 and binds copper.

@en

BACE1 cytoplasmic domain inter ...... dismutase-1 and binds copper.

@nl

prefLabel

BACE1 cytoplasmic domain inter ...... dismutase-1 and binds copper.

@en

BACE1 cytoplasmic domain inter ...... dismutase-1 and binds copper.

@nl

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P1433

Journal of Biological Chemistry

P1476

BACE1 cytoplasmic domain inter ...... e dismutase-1 and binds copper

@en

P2093

Barbara Angeletti

http://www.w3.org/2001/XMLSchema#string

Christopher Dennison

http://www.w3.org/2001/XMLSchema#string

Colin Dingwall

http://www.w3.org/2001/XMLSchema#string

Hinayana Bawagan

http://www.w3.org/2001/XMLSchema#string

Ishrut Hussain

http://www.w3.org/2001/XMLSchema#string

Katie B Freeman

http://www.w3.org/2001/XMLSchema#string

Maria E Tennant

http://www.w3.org/2001/XMLSchema#string

P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

BACE2 functions as an alternative alpha-secretase in cells

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

The copper chaperone for superoxide dismutase

Heterodimeric structure of superoxide dismutase in complex with its metallochaperone

Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90

P304

17930-17937

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scholarly article

P356

10.1074/JBC.M412034200

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P407

P433

18

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P478

280

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P50

Kevin J. Waldron

Christopher C. Miller

P577

2005-02-18T00:00:00Z

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P5875

8011800

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15722349

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P921

molecular chaperones