Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins
about
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionThe role of APP and BACE1 trafficking in APP processing and amyloid-β generationAlzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid raftsThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1Genome-wide prediction of SH2 domain targets using structural information and the FoldX algorithm.TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation.Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.Ubiquitin regulates GGA3-mediated degradation of BACE1Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes.Beta-secretase: structure, function, and evolution.Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors.Cargo adaptors: structures illuminate mechanisms regulating vesicle biogenesis.BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.Depletion of GGA3 stabilizes BACE and enhances beta-secretase activityGenetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease.Direct binding of the Kex2p cytosolic tail to the VHS domain of yeast Gga2p facilitates TGN to prevacuolar compartment transport and is regulated by phosphorylationStructure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's diseasebeta-Secretase as a therapeutic target for Alzheimer's disease.A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1.Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1.The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease.Identification and biology of β-secretase.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and BeyondTranscriptional and post-transcriptional regulation of β-secretase.The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion.Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptors.BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1.BACE1 binds GGA1;2;3
P2860
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P2860
Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Biochemical and structural cha ...... the VHS domain of GGA proteins
@ast
Biochemical and structural cha ...... the VHS domain of GGA proteins
@en
Biochemical and structural cha ...... the VHS domain of GGA proteins
@nl
type
label
Biochemical and structural cha ...... the VHS domain of GGA proteins
@ast
Biochemical and structural cha ...... the VHS domain of GGA proteins
@en
Biochemical and structural cha ...... the VHS domain of GGA proteins
@nl
prefLabel
Biochemical and structural cha ...... the VHS domain of GGA proteins
@ast
Biochemical and structural cha ...... the VHS domain of GGA proteins
@en
Biochemical and structural cha ...... the VHS domain of GGA proteins
@nl
P2093
P3181
P356
P1433
P1476
Biochemical and structural cha ...... the VHS domain of GGA proteins
@en
P2093
Gerald Koelsch
Guangyu Zhu
Jordan Tang
Xiangyuan He
Xuejun C Zhang
P304
12174-12180
P3181
P356
10.1021/BI035199H
P407
P577
2003-10-01T00:00:00Z