Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective. - Wikidata - awgldk - TriplyDB

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.

http://www.wikidata.org/entity/Q45300629

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Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis Molecular Insight into Substrate Recognition and Catalysis of Baeyer–Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model Effects of Sp1 overexpression on cultured human corneal stromal cells.Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.Transcriptional activation of REST by Sp1 in Huntington's disease models Anticancer drug mithramycin interacts with core histones: An additional mode of action of the DNA groove binder.Identification of a novel cell type-specific intronic enhancer of macrophage migration inhibitory factor (MIF) and its regulation by mithramycin.Does Huntingtin play a role in selective macroautophagy?Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway.Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease Bilateral gene interaction hierarchy analysis of the cell death gene response emphasizes the significance of cell cycle genes following unilateral traumatic brain injury Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood.The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system.Transcriptional signatures in Huntington's disease.Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT.Drug targeting of dysregulated transcription in Huntington's disease Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.REST: transcriptional and epigenetic regulator.The nuclear events guiding successful nerve regeneration.Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease Recent Trends in Detection of Huntingtin and Preclinical Models of Huntington's Disease Extracellular signal-related kinase 2/specificity protein 1/specificity protein 3/repressor element-1 silencing transcription factor pathway is involved in Aroclor 1254-induced toxicity in SH-SY5Y neuronal cells.Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies.Sp1 regulates human huntingtin gene expression.Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.MPTP's pathway of toxicity indicates central role of transcription factor SP1.Context-dependent dysregulation of transcription by mutant huntingtin.Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration.Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.p38/Sp1/Sp4/HDAC4/BDNF Axis Is a Novel Molecular Pathway of the Neurotoxic Effect of the Methylmercury Epigenetic modifications as novel therapeutic targets for Huntington's disease.

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Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.

http://www.wikidata.org/entity/Q45300629

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

@zh-my

2006年学术文章

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2006年學術文章

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2006年學術文章

@zh-hant

name

Sp1 is up-regulated in cellula ...... reduction is neuroprotective.

@en

Sp1 is up-regulated in cellula ...... reduction is neuroprotective.

@nl

type

label

Sp1 is up-regulated in cellula ...... reduction is neuroprotective.

@en

Sp1 is up-regulated in cellula ...... reduction is neuroprotective.

@nl

prefLabel

Sp1 is up-regulated in cellula ...... reduction is neuroprotective.

@en

Sp1 is up-regulated in cellula ...... reduction is neuroprotective.

@nl

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P1433

Journal of Biological Chemistry

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Sp1 is up-regulated in cellula ...... reduction is neuroprotective.

@en

P2093

Bhupinder Singh

http://www.w3.org/2001/XMLSchema#string

Birgit Zucker

http://www.w3.org/2001/XMLSchema#string

Caroline L Benn

http://www.w3.org/2001/XMLSchema#string

Derek P DiRocco

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Fran Norflus

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Jang-Ho J Cha

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Mary K Swindell

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Michelle Bejarano

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Raman Chopra

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Rodica Buzescu

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P2860

SUMO modification of Huntingtin and Huntington's disease pathology

Interaction of Huntington disease protein with transcriptional activator Sp1

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages

Functional characterization of the human Huntington's disease gene promoter

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1

Inducible expression of manganese superoxide dismutase by phorbol 12-myristate 13-acetate is mediated by Sp1 in endothelial cells

Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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16672-16680

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scholarly article

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10.1074/JBC.M511648200

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24

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281

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Robert J Ferrante

Steven M Hersch

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2006-04-04T00:00:00Z

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16595660

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P921

Huntington disease